Successful Lung Transplantation in a Case With Diffuse Pulmonary Arteriovenous Malformations and Hereditary Hemorrhagic Telangiectasia |
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| Authors: | H. Fukushima T. Mitsuhashi T. Oto Y. Sano K. F. Kusano K. Goto M. Okazaki H. Date Y. Kojima H. Yamagishi T. Takahashi |
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| Affiliation: | 1. Department of Pediatrics, School of Medicine, Keio University, , Tokyo, Japan;2. Department of Cancer and Thoracic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, , Okayama, Japan;3. Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, , Okayama, Japan;4. Department of Anesthesiology and Resuscitology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, , Okayama, Japan;5. Department of Thoracic Surgery, Kyoto University Graduate School of Medicine, , Kyoto, Japan |
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| Abstract: | Diffuse pulmonary arteriovenous malformations (AVMs) are associated with a poor prognosis and the therapeutic strategy remains controversial. We describe a pediatric patient with diffuse pulmonary AVMs associated with hereditary hemorrhagic telangiectasia (HHT), who presented with two cerebral AVMs in the parietal and occipital lobes as well. Of note, successful bilateral lung transplantation not only improved the hypoxemia but also resulted in size reduction of the cerebral AVMs. Although it is essential to consider involvements other than pulmonary AVMs, especially brain AVMs, to decide the indication, lung transplantation can be a viable therapeutic option for patients with diffuse pulmonary AVMs and HHT. |
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| Keywords: | Cerebral arteriovenous malformation hereditary hemorrhagic telangiectasia lung transplantation pulmonary arteriovenous malformation |
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