The antimanic‐like effect of phenytoin and carbamazepine on methylphenidate‐induced hyperlocomotion: role of voltage‐gated sodium channels |
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| Authors: | Denise AG Tonelli Marcela Pereira Isadora P Siba Bruno J Martynhak Diego Correia Plínio C Casarotto Caroline Biojone Francisco S Guimarães Samia LR Joca Roberto Andreatini |
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| Institution: | 1. Division of Biological Sciences, Department of Pharmacology, Universidade Federal do Paraná, , Curitiba, Paraná, 81540‐990 Brazil;2. Department of Pharmacology, School of Medicine of Ribeir?o Preto, University of S?o Paulo, , Ribeir?o Preto, S?o Paulo, 14049‐900 Brazil;3. Center for Interdisciplinary Research on Applied Neurosciences (NAPNA), University of S?o Paulo, , Ribeir?o Preto, S?o Paulo, 14049‐900 Brazil;4. Laboratory of Psychopharmacology, Department of Physics and Chemistry, School of Pharmaceutical Sciences of Ribeir?o Preto, University of S?o Paulo, , Ribeir?o Preto, S?o Paulo, 14040‐903 Brazil |
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| Abstract: | The objective of this study was to verify whether phenytoin modifies methylphenidate‐induced hyperlocomotion, an animal model for screening antimanic‐like drugs, and also evaluate the effect of veratrine, a voltage‐gated sodium channel opener, pretreatment on the effect of phenytoin in this model. Carbamazepine was used as a positive control. Methylphenidate (5 mg/kg, s.c.) increased open‐field locomotion, and phenytoin (5–10 mg/kg, i.p.) and carbamazepine (20 mg/kg, i.p.) blocked this effect. Veratrine (0.4 mg/kg, s.c.) pretreatment reversed the effects of phenytoin (10 mg/kg, i.p.) and carbamazepine (20 mg/kg, i.p.). Phenytoin (1–50 mg/kg, i.p.) and carbamazepine (10–20 mg/kg i.p.) alone did not change spontaneous locomotor activity. These results indicate that voltage‐gated sodium channels play an important role in antimanic‐like effects of phenytoin and carbamazepine on psychostimulant‐induced hyperlocomotion model. |
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| Keywords: | animal model anticonvulsant bipolar mania methylphenidate veratrine |
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