Is septal glucose metabolism altered in patients with left bundle branch block and ischemic cardiomyopathy? |
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| Authors: | Kerry Thompson George Saab David Birnie Benjamin J W Chow Heikki Ukkonen Karthik Ananthasubramaniam Robert A Dekemp Linda Garrard Terrence D Ruddy Jean N Dasilva Rob S B Beanlands |
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| Institution: | Division of Cardiology, National Cardiac PET Centre, University of Ottawa Heart Institute, Ottawa, Ontario, Canada. |
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| Abstract: | Left bundle branch block (LBBB) is common in patients with heart failure (HF) and contributes to left ventricular (LV) dysfunction. The abnormal septal motion may alter septal metabolic demand but this has not been well characterized in patients with ischemic cardiomyopathy (ICM) and LV dysfunction. The aim of this study was to determine the effect of LBBB on septal metabolism in patients with ICM, LV dysfunction, and LBBB. METHODS: Fifty-three patients with LV dysfunction and ICM were identified: 34 with LBBB, 19 with normal QRS (30% of this patient population. Absence of this finding was often associated with lateral wall perfusion defects, suggesting an alteration in the metabolic demand on the septum. This may have implications for HF therapies such as resynchronization and requires further study. |
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