粘附分子CD44v6和E—cadherin的表达与甲状腺乳头状癌侵袭转移的关系

目的 探讨粘附分子CD44v6和E－cadherin表达与甲状腺乳头状瘤（PTC）侵袭转移的关系。 方法 应用S－P免疫组织化学方法检测58例甲状腺乳头状癌组织中CD44v6和E－cadherin的表达。结果 甲状腺乳头状癌组织中CD44v6和E－cadherin表达阳性率分别为72．4％和41．4％；CD44v6表达阳性率与PTC的侵袭和转移呈正相关（P＜0．05），而E-cadherin表达阳性率与PTC的侵袭和转移呈负相关（P＜0．01），且两种粘附分子在PTC中的阳性表达呈负相关性（P＜0．05）。结论 粘附分子表达与PTC侵袭和转移密切相关，检测CD44v6和E－cadherin的表达可作为判断甲状腺乳头状癌预后的参考指标。

ADHESIVE MOLECULE EXPRESSION IN RELATION TO INVASION AND METASTASIS IN THYROID PAPILLARY CARCINOMA

Objective To investigate the correlation of adhesive molecule expressions with potential of invasion and metastasis in papillary thyroid carcinoma (PTC). Methods S P immunohistochemical method was used to detect CD44v6 and E cadherin expression in 58 cases of PTC. Results The positive rates of CD44v6 and E cadherin in PTC were 72.40% and 41.4% respectively. There was a positive correlation between CD44v6 expression and tumor invasive and metastatic potential in PTC ( P <0.05), and a reverse correlation between E cadherin expression and the potential ( P < 0.01). Moreover,there was a reverse correlation between the CD44v6 and E cadherin expression in PTC( P <0.05). Conclusion These data show a correlation between the adhesive molecule expression and the potential of invasion and metastasis in PTC. CD44v6 and E cadherin may be prognostic indicators in PTC.