| 寡聚体透明质酸逆转A549/DDP细胞耐药作用的研究 |
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| 引用本文： | 王宝中,司海运,王丽萍,王保君,杨宁. 寡聚体透明质酸逆转A549/DDP细胞耐药作用的研究[J]. 肿瘤基础与临床, 2006, 19(2): 118-119 |
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| 作者姓名： | 王宝中 司海运 王丽萍 王保君 杨宁 |
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| 作者单位： | 1. 聊城市人民医院,山东,聊城,252000
2. 临西县第二人民医院,河北,临西,054900 |
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| 摘 要： | 目的 研究寡聚体透明质酸逆转A549／DDP细胞耐药的作用。方法 MTT法研究寡聚体透明质酸对A549／DDP耐药逆转作用，流式细胞术测定细胞表面耐药相关蛋白P-gP、MRP的表达及凋亡调控蛋白P53、bcl-2的表达。结果 寡聚体透明质酸可提高A549／DDP对化疗药物的敏感性，使P-gp、MRP表达下降，P53表达增高。结论 寡聚体透明质酸有部分逆转A549／DDP耐药及诱导凋亡的作用。
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| 关 键 词： | 寡聚体透明质酸 逆转耐药 诱导凋亡 |
| 文章编号： | 1673-5412（2006）02-0118-02 |
| 收稿时间： | 2005-08-15 |
| 修稿时间： | 2005-08-15 |
A Study of the Effects of Reversing Drug Resistant of Hyaluronate Oligomerson A549/DDP |
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| Wang Baozhong,Si Haiyun,Wang Liping,Wang Baojun,Yang Ning. A Study of the Effects of Reversing Drug Resistant of Hyaluronate Oligomerson A549/DDP[J]. journal of basic and clinical oncology, 2006, 19(2): 118-119 |
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| Authors: | Wang Baozhong Si Haiyun Wang Liping Wang Baojun Yang Ning |
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| Abstract: | Objective To study the effects of hyaluronate oligomers on reversing drug-resistance and apoptosis of A549/DDP.Methods In application of tetrazolium dye assay to study the reversal effects of hyaluronate oligomers on A549/DDP.MDR related protein P-gp,MRP,apoptosis adjusted protein P53 and bcl-2 were detected by flow cytometry(FCM).Results Hyaluronate oligomers could enhance the sensitivity of A549/DDP on DDP and expression of P53,and reduce the expression of P-gp and MRP.Conclusions Hyaluronate oligomers could reverse multidrug resistance in A549/DDP. |
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| Keywords: | A549/DDP |
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