| 桃红四物汤HPLC指纹图谱的总量统计矩及一次稳态投料量分析 |
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| 引用本文： | 李海英,贺鹏,樊启猛,贺玉婷,杨岩,潘雪,肖美凤,贺福元.桃红四物汤HPLC指纹图谱的总量统计矩及一次稳态投料量分析[J].中国实验方剂学杂志,2019,25(15):37-43. |
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| 作者姓名： | 李海英 贺鹏 樊启猛 贺玉婷 杨岩 潘雪 肖美凤 贺福元 |
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| 作者单位： | 湖南中医药大学 药学院, 中药成药性与制剂制备湖南省重点实验室, 中医药超分子机理与数理特征化实验室, 长沙 410208,湖南中医药大学 药学院, 中药成药性与制剂制备湖南省重点实验室, 中医药超分子机理与数理特征化实验室, 长沙 410208,湖南中医药大学 药学院, 中药成药性与制剂制备湖南省重点实验室, 中医药超分子机理与数理特征化实验室, 长沙 410208,湖南中医药大学 药学院, 中药成药性与制剂制备湖南省重点实验室, 中医药超分子机理与数理特征化实验室, 长沙 410208,湖南中医药大学 药学院, 中药成药性与制剂制备湖南省重点实验室, 中医药超分子机理与数理特征化实验室, 长沙 410208,湖南中医药大学 药学院, 中药成药性与制剂制备湖南省重点实验室, 中医药超分子机理与数理特征化实验室, 长沙 410208,湖南中医药大学 药学院, 中药成药性与制剂制备湖南省重点实验室, 中医药超分子机理与数理特征化实验室, 长沙 410208,湖南中医药大学 药学院, 中药成药性与制剂制备湖南省重点实验室, 中医药超分子机理与数理特征化实验室, 长沙 410208 |
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| 基金项目： | 国家自然科学基金项目（81573691，81703824，81874507）；湖南省自然科学基金项目（2017JJ3236，2016JJ2097）；湖湘中药资源保护与利用2011协同创新中心建设项目 |
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| 摘 要： | 目的:建立中药及经典名方HPLC指纹图谱总量统计矩、信息量及一次投料量数学模型并进行实验验证。方法:运用总量统计矩原理和Hardy-Weinberg平衡群体一次稳态投料量计算方法,对来自不同产地的15批桃红四物汤原药材、饮片及复方制剂总量统计矩及一次稳态投料量进行研究。结果:除了总量一阶矩外,各药材、饮片及复方总量零阶矩、总量二阶矩、信息熵、信息量的RSD均 10%。用单味原药材投料,除当归外(142. 34 kg),按全方累积的信息量的RSD变化计算出的一次稳态投料量最大(59. 10 kg);而按全方的比例投料,全方一次稳态投料量最大(958. 57 kg)。用炮制品投料,除酒红花外(83. 28 kg),全方累积的一次稳态投料量最大(73. 18 kg);按全方投料,炮制品一次稳态处方投料量均与原药材相同。原药材或炮制品组成的复方,其一次稳态投料量经常大于单味药材的一次稳态投料量。结论:中药成分受遗传多态性控制,中药色谱作用特征(成分种类)相近而作用强度(成分含量)不同,总量一阶矩、信息熵稳定说明中药多成分体系总体化学结构的印迹作用趋势稳定;桃红四物汤各药材及复方一次稳态投料量均远大于处方量,可为工业化大生产提供借鉴。
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| 关 键 词： | 经典名方 桃红四物汤 总量统计矩 一次稳态投料量 均一性 稳定性 指纹图谱 |
| 收稿时间： | 2019/1/24 0:00:00 |
Analysis of Total Statistical Moment and One-time Steady-state Feeding Quantity of HPLC Fingerprint of Taohong Siwutang |
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| LI Hai-ying,HE Peng,FAN Qi-meng,HE Yu-ting,YANG Yan,PAN Xue,XIAO Mei-feng and HE Fu-yuan.Analysis of Total Statistical Moment and One-time Steady-state Feeding Quantity of HPLC Fingerprint of Taohong Siwutang[J].China Journal of Experimental Traditional Medical Formulae,2019,25(15):37-43. |
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| Authors: | LI Hai-ying HE Peng FAN Qi-meng HE Yu-ting YANG Yan PAN Xue XIAO Mei-feng and HE Fu-yuan |
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| Institution: | College of Pharmacy, Hunan Provincial Key Laboratory of Druggability and Preparation Modification for Traditional Chinese Medicine, Laboratory of Supramolecular Mechanism and Mathematic-Physics Chracterization for Chinese Materia Medica, Hunan University of Chinese Medicine, Changsha 410208, China,College of Pharmacy, Hunan Provincial Key Laboratory of Druggability and Preparation Modification for Traditional Chinese Medicine, Laboratory of Supramolecular Mechanism and Mathematic-Physics Chracterization for Chinese Materia Medica, Hunan University of Chinese Medicine, Changsha 410208, China,College of Pharmacy, Hunan Provincial Key Laboratory of Druggability and Preparation Modification for Traditional Chinese Medicine, Laboratory of Supramolecular Mechanism and Mathematic-Physics Chracterization for Chinese Materia Medica, Hunan University of Chinese Medicine, Changsha 410208, China,College of Pharmacy, Hunan Provincial Key Laboratory of Druggability and Preparation Modification for Traditional Chinese Medicine, Laboratory of Supramolecular Mechanism and Mathematic-Physics Chracterization for Chinese Materia Medica, Hunan University of Chinese Medicine, Changsha 410208, China,College of Pharmacy, Hunan Provincial Key Laboratory of Druggability and Preparation Modification for Traditional Chinese Medicine, Laboratory of Supramolecular Mechanism and Mathematic-Physics Chracterization for Chinese Materia Medica, Hunan University of Chinese Medicine, Changsha 410208, China,College of Pharmacy, Hunan Provincial Key Laboratory of Druggability and Preparation Modification for Traditional Chinese Medicine, Laboratory of Supramolecular Mechanism and Mathematic-Physics Chracterization for Chinese Materia Medica, Hunan University of Chinese Medicine, Changsha 410208, China,College of Pharmacy, Hunan Provincial Key Laboratory of Druggability and Preparation Modification for Traditional Chinese Medicine, Laboratory of Supramolecular Mechanism and Mathematic-Physics Chracterization for Chinese Materia Medica, Hunan University of Chinese Medicine, Changsha 410208, China and College of Pharmacy, Hunan Provincial Key Laboratory of Druggability and Preparation Modification for Traditional Chinese Medicine, Laboratory of Supramolecular Mechanism and Mathematic-Physics Chracterization for Chinese Materia Medica, Hunan University of Chinese Medicine, Changsha 410208, China |
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| Abstract: | |
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| Keywords: | classical famous formulas Taohong Siwutang total statistical moment one-time steady-state feeding quantity uniformity stability fingerprint |
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