| 降钙素基因相关肽及内皮素A受体与蛛网膜下腔出血 |
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| 引用本文： | 宋锦宁,张明,梁琦,隋龙,郗磊,王文博. 降钙素基因相关肽及内皮素A受体与蛛网膜下腔出血[J]. 中国神经再生研究, 2011, 6(1): 47-54 |
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| 作者姓名： | 宋锦宁 张明 梁琦 隋龙 郗磊 王文博 |
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| 作者单位： | 西安交通大学医学院第一附属医院神经外科,西安交通大学医学院第一附属医院神经内科,Department of Neurosurgery, First Affiliated Hospital, College of Medicine, Xi’an Jiaotong University, Xi’an 710061, Shaanxi Province, China,Department of Neurosurgery, First Affiliated Hospital, College of Medicine, Xi’an Jiaotong University, Xi’an 710061, Shaanxi Province, China,Department of Neurosurgery, First Affiliated Hospital, College of Medicine, Xi’an Jiaotong University, Xi’an 710061, Shaanxi Province, China,Department of Neurosurgery, First Affiliated Hospital, College of Medicine, Xi’an Jiaotong University, Xi’an 710061, Shaanxi Province, China |
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| 基金项目： | the National 863 Project of China, No. 2006AA02Z4Z4; the National Natural Science Foundation of China, No. 30870844; the New Century Excellent Talent Support Project of Ministry of Education, No. NCET-05-0831; the “13115” Special Fund for Major Science and Technology Projects of Shaanxi Province, No. 2008ZDKG-66 |
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| 摘 要： | Numerous studies have demonstrated that endothelin-1 combines with endothelin receptor A,resulting in intense vasoconstriction.Although calcitonin gene-related peptide(CGRP) suppresses endothelin-1,CGRP and endothelin receptor A exhibit direct biological effects on brain tissue.The present study analyzed CGRP and endothelin receptor A expression following subarachnoid hemorrhage in rabbits using immunohistochemistry.CGRP expression was significant at 5 days after model establishment,and endothelin receptor A expression was significant at 3 days after model induction.The perimeter of the basilar artery was measured to determine the amount of cerebral vasospasm.Analytical results revealed a significantly shortened basilar artery perimeter following subarachnoid hemorrhage.Changes in the basilar artery perimeter were negatively associated with endothelin receptor A expression,but positively correlated with CGRP expression in vessels.These results suggest that following subarachnoid hemorrhage,CGRP and endothelin receptor A expressions dynamically changed in brain vessels and tissues,although these changes were not synchronous.Changes in endothelin receptor A expression exhibited a significant effect on the occurrence and development of delayed cerebral vasospasm and delayed neuronal death,while CGRP relaxed vessels and protected nerves.
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| 关 键 词： | calcitonin gene-related peptide endothelin receptor A subarachnoid hemorrhage cerebral vasospasm brain injury neural regeneration |
Correlation of calcitonin gene-related peptide and endothelin receptor A with subarachnoid hemorrhage |
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| Jinning Song,Ming Zhang,Qi Liang,Long Sui,Lei Xi,Wenbo Wang. Correlation of calcitonin gene-related peptide and endothelin receptor A with subarachnoid hemorrhage[J]. Neural Regeneration Research, 2011, 6(1): 47-54 |
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| Authors: | Jinning Song Ming Zhang Qi Liang Long Sui Lei Xi Wenbo Wang |
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| Affiliation: | Department of Neurosurgery,First Affiliated Hospital,College of Medicine,Xi’an Jiaotong University,Xi’an 710061,Shaanxi Province,China |
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| Abstract: | Numerous studies have demonstrated that endothelin-1 combines with endothelin receptor A, resulting in intense vasoconstriction. Although calcitonin gene-related peptide (CGRP) suppresses endothelin-1, CGRP and endothelin receptor A exhibit direct biological effects on brain tissue. The present study analyzed CGRP and endothelin receptor A expression following subarachnoid hemorrhage in rabbits using immunohistochemistry. CGRP expression was significant at 5 days after model establishment, and endothelin receptor A expression was significant at 3 days after model induction. The perimeter of the basilar artery was measured to determine the amount of cerebral vasospasm. Analytical results revealed a significantly shortened basilar artery perimeter following subarachnoid hemorrhage. Changes in the basilar artery perimeter were negatively associated with endothelin receptor A expression, but positively correlated with CGRP expression in vessels. These results suggest that following subarachnoid hemorrhage, CGRP and endothelin receptor A expressions dynamically changed in brain vessels and tissues, although these changes were not synchronous. Changes in endothelin receptor A expression exhibited a significant effect on the occurrence and development of delayed cerebral vasospasm and delayed neuronal death, while CGRP relaxed vessels and protected nerves. |
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| Keywords: | calcitonin gene-related peptide endothelin receptor A subarachnoid hemorrhage cerebral vasospasm brain injury neural regeneration |
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