Mechanism of action of the new cardiotonic suphan on calcium exchange in cardiomyocytes |
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Authors: | P. A. Galenko-Yaroshevskii A. I. Khankoeva A. S. Dukhanin |
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Affiliation: | (1) Department of Pharmacology, Kuban Medical Academy, Krasnodar;(2) Department of Molecular Pharmacology with a Course in Radiobiology, Russian State Medical University, Moscow |
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Abstract: | Effects of suphan, a new cardiotonic agent containing succinyl tryptophan, on the entry of Ca2+ into rat cardiomyocytes, its intracellular compartmentalization, and its exit from these cells were evaluatedin vitro. It was found that the recorded sulfan-induced rise of intracellular calcium was due to Ca2+ entering the cell via L-type calcium channels, and that a reversible reduction of its concentration in the sarcoplasm occurred through its accumulation in the sarcoplasmic reticulum and was blocked by the specific Ca2+-ATPase inhibitor thapsigargin (10 μM). Suphan did not alter the activity of Na+/Ca2+ exchange in a concentration range of 5–150 μg/ml. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 122, No. 7, pp. 57–59, July, 1996 |
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Keywords: | calcium cardiomyocytes suphan Ca-ATPase |
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