抗心磷脂抗体与脑梗死关系的研究

目的 探讨抗心磷脂抗体(anti-eardiolipin antibodies,ACA)与脑梗死的关系.方法 应用酶联免疫吸附实验(ELISA)检测150例脑梗死患者发病后3d内血清ACA阳性率,并与进展性脑梗死组、脑出血组及正常对照组比较.结果 进展性脑梗死组ACA阳性率(60.8%)高于腩梗死组(48%),差异有统计学意义(P<0.05).脑梗死组ACA阳性率(48%)明显高于脑出血组(21.8%)、正常对照组(17.2%),差异有显著统计学意义(P<0.01).脑出血组ACA阳性率(21.8%)虽高于正常对照组,但差异无统计学意义(P>0.05).进一步分析脑梗死组及进展性脑梗死组中年龄<50岁患者的ACA阳性率(59%)高于年龄>50岁患者(46%),差异有统计学意义(P<0.05).结论 脑梗死患者急性期ACA阳性率高,尤其是年龄<50岁者,提示ACA的升高与脑梗死的形成关系密切,对于脑梗死疾病的发生及预后可能具有预测意义,从而对临床早期干预起一定的指导作用.

Abstract：

Objective To study the relationship between anti-cardiolipin antibodys(ACA)and cerebral infarction (CI).Methods The positive rate of serum ACA were detemined by enzyme linked immunosorbent assay(ELISA)in 150 patients with CI at thirth day after the onset of the disease.The results were compared with progression CI group,intracerebral hemorrhage(ICH)group and nomal control group.Results The positive rate of ACA in progression CI group (60.8%)was higher than CI group(48%)(P<0.05).The positive rate of ACA in CI group(48%)wag significantly higher than ICH(21.8%)and nomal control group(17.2%)(P<0.01).The positive rate of ACA in ICH group was higher than nomal control group,but there wa8 no statistical significance(P>0.05).The patients with CI and progression CI under 50 years old had hisher positive rate of ACA than the patients over 50 years old(P<0.01).Conclusions High positive rate of ACA appeares at acute phase of CI and in the patients under 50 years old.There is close relationship between anti-eardiolipin antibodys and cerebral infarction.It would forecast with disease and it,s prognosis and would guide to the early intervention.

Study of relationship between anti-cardiolipin antibodys and cerebral infarction

Objective To study the relationship between anti-cardiolipin antibodys(ACA)and cerebral infarction (CI).Methods The positive rate of serum ACA were detemined by enzyme linked immunosorbent assay(ELISA)in 150 patients with CI at thirth day after the onset of the disease.The results were compared with progression CI group,intracerebral hemorrhage(ICH)group and nomal control group.Results The positive rate of ACA in progression CI group (60.8%)was higher than CI group(48%)(P<0.05).The positive rate of ACA in CI group(48%)wag significantly higher than ICH(21.8%)and nomal control group(17.2%)(P<0.01).The positive rate of ACA in ICH group was higher than nomal control group,but there wa8 no statistical significance(P>0.05).The patients with CI and progression CI under 50 years old had hisher positive rate of ACA than the patients over 50 years old(P<0.01).Conclusions High positive rate of ACA appeares at acute phase of CI and in the patients under 50 years old.There is close relationship between anti-eardiolipin antibodys and cerebral infarction.It would forecast with disease and it,s prognosis and would guide to the early intervention.