| 运动训练对大鼠脑缺血再灌注后神经修复及GAP-43和Neurocan表达的影响 |
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| 引用本文： | 廖杨平,程道宾,苏丽,赵伟佳.运动训练对大鼠脑缺血再灌注后神经修复及GAP-43和Neurocan表达的影响[J].中风与神经疾病杂志,2011,28(4). |
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| 作者姓名： | 廖杨平 程道宾 苏丽 赵伟佳 |
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| 作者单位： | 广西医科大学第一附属医院神经内科,广西南宁,530021 |
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| 摘 要： | 目的 观察运动训练对大鼠脑缺血再灌注后不同时间神经修复及GAP-43与Neurocan表达的影响.方法 健康雄性Wistar大鼠72只,随机分成运动训练组、对照组、假手术组.采用线栓法制作一侧大脑中动脉闭塞(MCAO)模型,以神经功能缺损评分和Morris水迷宫试验进行神经功能评价,免疫组化法观察对脑缺血周围GAP-43与Neuorcan的表达.结果 与对照组比较,脑缺血再灌注后14d、21d,运动组的肢体运动及记忆功能明显恢复;缺血再灌注后7d,对照组缺血周围出现GAP-43阳性细胞,14d减少,21d、28d明显减少,运动组GAP-43表达在14d、21d、28d较对照组显著增加(P<0.05).Neurocan阳性细胞在对照组缺血再灌注7d出现,14d达高峰,21d、28d时下降;运动组Neurocan表达在缺血再灌注14d、21d、28d较对照组显著减少(P<0.05).结论 运动训练上调大鼠脑缺血区GAP-43表达与下调Neurocan表达,可能是其促进脑损伤区中枢神经修复的重要机制之一.
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| 关 键 词： | 运动训练 脑缺血再灌注 |
Effects of physical exercises on neural reparation and the expression of GAP-43 and Neurocan after cerebral ischemia-reperfusion in rats |
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| LIAO Yang-ping,CHENG Dao-bin,SU-Li,et al..Effects of physical exercises on neural reparation and the expression of GAP-43 and Neurocan after cerebral ischemia-reperfusion in rats[J].Journal of Apoplexy and Nervous Diseases,2011,28(4). |
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| Authors: | LIAO Yang-ping CHENG Dao-bin SU-Li |
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| Institution: | LIAO Yang-ping,CHENG Dao-bin,SU-Li,et al.(Department of Neurology,The First affiliated Hospital,Guangxi Medical University,Nanning 530021,China) |
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| Abstract: | Objective To observe the effects of physical exercises on the grade of behavior and the expression of GAP-43 and Neurocan during the different time points after the cerebral ischemia and reperfusion in rat model.Methods 72 Healthy female Wistar rats were randomly divided into 3 groups:Exercising group(E group,n=24),ischemia-reperfusion group(I/R group,n=24) and sham group(S group,n=24).The middle artery cerebral occlusion(MACO) was performed with the ligation of artery with a nylon suture for 90 mins.6 rats... |
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| Keywords: | GAP-43 Neuorcan |
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