| 抗ICAM-1抗体联合IGF-1治疗猫脑缺血再灌注损伤的有效性研究 |
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| 引用本文： | 贺丹,颜立群,刘怀军,姚洁,张玉笛,刘宗杰. 抗ICAM-1抗体联合IGF-1治疗猫脑缺血再灌注损伤的有效性研究[J]. 中风与神经疾病杂志, 2011, 28(1) |
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| 作者姓名： | 贺丹 颜立群 刘怀军 姚洁 张玉笛 刘宗杰 |
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| 作者单位： | 1. 河北医科大学第二医院神经内科,河北,石家庄,050000
2. 河北医科大学第二医院医学影像科,河北,石家庄,050000 |
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| 摘 要： | 目的 评价联合应用抗ICAM-1抗体和IGF-1在治疗脑缺血再灌注损伤中的作用.方法 24只健康家猫,随机分成4组:对照组、抗ICAM-1抗体治疗组、IGF-1治疗组和联合治疗组,每组6只动物,采用经眼眶入路夹闭大脑中动脉M2段的方法建立家脑猫缺血再灌注模型.于再灌注后3d和7d进行Philips神经功能缺损评分、磁共振T2WI高信号体积测量和TUNAL法凋亡细胞计数.结果 联合治疗组7d时神经功能评分增加、最终梗死体积缩小、凋亡细胞数减少(分别为:40.83±4.36;0.49±0.06;21.59±7.28),明显优于抗ICAM-1抗体治疗组(分别为:55.83±3;1.03±0.08;34.03±0.08)和IGF-1治疗组(分别为:61.00±2.96;0.73±0.07;39.73±0.07),P＜0.05.结论 应用抗ICAM-1抗体和IGF-1治疗脑梗死,能够从多环节减轻和阻断脑缺血再灌注损伤的病理过程,显著提高脑梗死的疗效.
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| 关 键 词： | 缺血再灌注损伤 抗细胞间粘附因子-1抗体 胰岛素样生长因子-1 神经保护 凋亡 猫 |
Effective study with anti-ICAM-1 antibody and IGF-1 in focal cerebral ischemia-reperfusion injury of cat |
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| HE Dan,YAN Li-qun,LIU Huai-jun,et al.. Effective study with anti-ICAM-1 antibody and IGF-1 in focal cerebral ischemia-reperfusion injury of cat[J]. Journal of Apoplexy and Nervous Diseases, 2011, 28(1) |
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| Authors: | HE Dan YAN Li-qun LIU Huai-jun et al. |
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| Affiliation: | HE Dan,YAN Li-qun,LIU Huai-jun,et al.(Department of Neurology,The Second Hospital of Hebei Medical Universitay,Shijiazhuang 050000,China) |
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| Abstract: | Objective To evaluate the effect of anti-ICAM-1 antibody and IGF-1 on cerebral focal ischemia-reperfusion injury.Methods Twenty-four cats were divided randomly into four groups:control group,anti-ICAM-1 antibody treatment group,IGF-1 treatment group and combined group.There were six animals in each group.The MCAO model of cerebral focal ischemia-reperfusion were establish by clipped M2 segment of the middle cerebral aterial through the eye orbit.The animals were evaluated for neuro-function by the Philips' ... |
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| Keywords: | Ischemia-reperfusion injury Anti-ICAM-1 antibody IGF-1 Neuroprotectant Apoptosis Cat |
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