TPH基因A218C多态性与愤怒启动及控制特质的关系

目的:探讨TPH基因A218C多态性与愤怒启动及控制特质的关系。方法:采用状态-特质愤怒表达量表2(STAXI-2)筛选被试,经采血、酚-氯仿法提取DNA、PCR-LDR法基因分型后,对数据进行统计分析。结果:①高特质怒被试3个基因型组男性控制发怒(AC-O)得分差异有统计学意义(P0.05)。②低特质怒被试3个基因型组以下得分差异有统计学意义(P0.05):怒的控制(AC),控制发怒(AC-O),控制郁怒(AC-I),女性控制发怒(AC-O)。结论:TPH基因A218C多态性与我国正常大学生中高特质怒男性的控制发怒特质有关,还与我国正常大学生中低特质怒者怒的控制特质、控制发怒特质、控制郁怒特质及低特质怒女性的控制发怒特质有关。

Asociation between hydroxylase gene A218C polymorphism and anger started as well as anger control trait

Objective: To discuss the association of tryptophan hydroxylase gene A218C polymorphism and anger started as well as anger control trait.Methods: After the subjects were selected by STAXI-2 questionnaire,blood of them was sampled,DNA was extracted by phenol–chloroform method,genotyped by PCR-LDR method,and data was statistically analyzed.Results: ①For high trait anger subjects,there was statistical significance of the scores of anger control-out(AC-O) of male in three genotype groups(P<0.05).②For low trait anger subjects,there was statistical significance of the following scores of the subjects in three genotype groups(P<0.05): anger control(AC),anger control-out(AC-0),anger control-in(AC-I) and anger control-out of female(AC-0).Conclusion: There was the association of TPH gene A218C polymorphism with anger control-out trait of normal male college students with high trait anger in China.The locus polymorphism was also related to the following anger traits of normal college students with low trait anger in China: anger control trait,anger control-out trait,anger control-in trait,anger control-out trait of female.