铁蛋白与糖尿病肾病早期微炎症状态的关系

【目的】探讨铁蛋白与糖尿病肾病（Diabetic nephropathy ，DN）早期微炎症状态的关系。【方法】本院门诊及住院的2型糖尿病（Type 2 Diabetes Mellitus ，T2DM）患者120例，分为正常白蛋白尿组、早期DN组、临床DN组，各40例，以同期健康体检正常40例为对照组。检测4组对象的血清铁蛋白（SF）及炎症因子高敏反应蛋白（hs-CRP）、肿瘤坏死因子（TNF-α）、白介素-6（IL-6）水平。【结果】与健康对照组比较，SF水平、炎症因子指标明显升高（P＜0．01）；随着DN 的进展，SF及炎症因子的水平相应升高，DN 各组间差异有统计学意义（P＜0．05）；DN患者SF升高与炎症因子的水平呈正相关（r＞0．1，P＜0．01）。【结论】体内铁负荷过重即过高的SF参与了早期DN患者机体的微炎症状态，诱导机体炎症因子水平的升高，从而参与了DN的发生和发展过程。

Relationship Between Ferritin and Microinflammation Status in the Early Stage of Diabetic Ne-phropathy

Objective]To explore the relationship between ferritin and microinflammation status in the early stage of diabetic nephropathy（DN） .Methods]Totally 120 patients with type 2 diabetes mellitus（T2DM） in our hospital were divided into normal proteinuria group ,early DN group and clinical DN group with 40 patients in each group .Meanwhile ,40 healthy subjected were selected as the control group .Serum ferrtin and inflammatory factors（hs-CRP ,TNF-αand IL-6） of 4 groups were measured .Results] Compared with the control group ,serum ferritin and inflammatory factors were increased obviously （ P〈0 .01） .With the progression of DN ,serum ferritin and inflammatory factors were increased correspondingly ,and there was significant difference between DN groups （ P 〈0 .05） .The elevation of serum ferritin in DN patients was positively related with inflammatory factors （ r 〉0 .1 ,P〈0 .01） .Conclusion]The overload of iron or over high ferritin may participate in body microinflammation status of patients with early DN and induce the elevation of body inflammatory factors ,and thus participate in the genesis and development of DN .