| 2型糖尿病肾病患者血同型半胱氨酸变化及意义分析 |
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| 引用本文： | 邓利娟,吴永新. 2型糖尿病肾病患者血同型半胱氨酸变化及意义分析[J]. 医学临床研究, 2014, 0(8): 1557-1558 |
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| 作者姓名： | 邓利娟 吴永新 |
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| 作者单位： | 邓利娟 (广东省梅州市人民医院内分泌科,广东 梅州,514000)； 吴永新 (广东省梅州市人民医院内分泌科,广东 梅州,514000)； |
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| 摘 要： | 【目的】分析血清同型半胱氨酸（Hcy）在2型糖尿病肾病患者中的变化及其意义。【方法】2012年2月至2013年12月在本院就诊的2型糖尿病（T2DM）患者201例；按照尿白蛋白排泄率测定结果分为A组（单纯糖尿病64例）、B组（糖尿病并早期肾病72例）、C组（糖尿病并临床期肾病65例）、以同期健康体检结果正常者53例作为对照组（D组）；分别测定其空腹血糖（FBG），肌酐（SCr），血尿素氮（BUN），Hcy等指标并进行统计学分析。【结果】A ，B，C组与D组比较Hcy及其他检测指标水平均显著升高（P ＜0．05），B、C组除FBG外，其他指标均显著高于A组（P＜0．01，P ＜0．05）．【结论】高同型半胱氨酸血症是T2DM并肾病患者主要危险因素。
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| 关 键 词： | 半胱氨酸/血液 糖尿病肾病/血液 白蛋白尿 危险因素 |
Change of Homocysteine in Patients with Type 2 Diabetic Nephropathy and Its Significance |
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| DENG Li-juan,WU Yong-xin. Change of Homocysteine in Patients with Type 2 Diabetic Nephropathy and Its Significance[J]. Journal of Clinical Research, 2014, 0(8): 1557-1558 |
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| Authors: | DENG Li-juan WU Yong-xin |
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| Affiliation: | (Department of Endocrinology, the People＇s Hospital of Meizhou City, Guangdong 514000, China ) |
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| Abstract: | [Objective]To analyze the change of serum homocysteine（Hcy） in patients with type 2 diabetic nephropathy and its significance .[Methods] Patients with type 2 diabetes mellitus in our hospital from Feb . 2012 to Dec .2013 were selected .According to urinary albumin excretion rate（UAER） determination results , all patients were divided into group A （simple diabetic group） ,group B（diabetes mellitus with early nephropathy） ,group C（diabetes mellitus with clinical nephropathy ） and group D（normal healthy control group） .FBG , SCr ,BUN and Hcy were measured and analyzed by statistics .[Results] Compared with control group ,Hcy levels in group A ,B and C were markedly increased ,and there was significant difference（ P 〈0 .05） .[Conclusion] Hyperhomocysteinaemia is an independent risk factor of type 2 diabetic nephropathy . |
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| Keywords: | Cysteine/BL Diabetic Nephropathies/BL Albuminuria Risk Factors |
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