舒筋止痛涂膜剂中川芎和肉桂提取工艺研究

目的:筛选出舒筋止痛涂膜剂最佳提取工艺。方法:以乌头碱含量为指标,以渗漉法、冷浸法、回流法、水提法为考察因素,进行提取方法筛选,以浸泡时间、乙醇用量、乙醇浓度、液滴速度为考察因素,采用L9(34)正交试验筛选舒筋止痛涂膜剂最佳提取工艺条件。同时以肉桂挥发油含量为指标,进行肉桂挥发油最佳提取工艺研究。结果:川乌最佳提取方法为冷浸法,最佳提取工艺条件为加75%乙醇,12倍药材量醇,浸泡48 h以3.5 mL/min速度放液。肉桂挥发油最佳提取工艺为不浸泡,加8倍药材量水,回流提取6 h。结论:该提取工艺科学、合理、可行。

Extraction Technique Research of Shujinzhitong Preparation

Objective: To screen the best extraction technique of shijinzhitong preparation.Methods: With content of acoitine as index,methods of ooze,cold soak,inverse flow and water extraction were screened and try to find the best extraction method among them.With soak time of medicinal material in extraction liquid,among of alcohol which used to extraction, alcohol concentration and dropping speed of ooze method,the best extraction technique was optimized by L_9(3~4)orthogonal test.With volatilize oil of the rhizome of Chinese monkshood as index,the best extraction method was optimized.Results: the best extraction method of volatilize oil of the rhizome of Chinese monkshood is 70%alcohol,amount of alcohol which is 12 times of medicinal material,soaping 48 h and 3.5 mL/min dropping speed.The best extraction method of the rhizome of Chinese monkshood was not soaped,added 8 times amount of the rhizome of Chinese monkshood and extracted 6 h.Conclusion: the optimized extraction technique is stable and feasible.