退热合剂工艺筛选的正交实验研究

目的]探讨退热合剂（由麻黄、石膏、知母、板蓝根、白茅根、葛根等中药组成）的最佳制剂工艺。方法]采用正交实验方法。用干酵母造成大鼠发热模型。以大鼠体温下降为筛选指标。对退热合剂工艺进行优化筛选。结果]退热合剂的最佳工艺流程是：药物洗净（石膏粉碎）-浸渍1h-石膏加10倍水先煎1h-余下各味药加10倍水与石膏合并共煎1h1次-提油-过滤-浓缩煎液-重蒸挥发油-合并两液，制成浓度1kg/L的煎液。

Process Technology for Antipyretic Mixture Screening by Orthogonal Test

Objective] To optimize the technology for Antipyretic Mixture (AM), which is mainly composed of Herba Ephedrae, Gypsum Fibrosum (GF), Rhizoma Amenarrhenae, Radix Isatidis, Rhizoma Imperatae, Radix Puerariae, etc. . Methods] Orthogonal test was applied for the screening of technology. Rat model of fever was induced by dried yeast and body temperature served as the screening index. Results & Conclusion] The optimal process was as follow: (1) cleaning the herbs and smashing Gypsum Fibrosum into pieces and then soaking for one hour; (2) decocting the herbs with 10-fold water for one hour (Gypsum Fibrosum decocted first for one hour) ; (3) extracting the volatile oil, filtering and then concentrating the decoction; (4) evaporating again the volatile oil; (5) mixing the solutions and preparing as 1 kg/L oral liquid.