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高压氧对心肌梗死大鼠模型梗死面积及左室功能的影响
引用本文:任旭荣,黄晨.高压氧对心肌梗死大鼠模型梗死面积及左室功能的影响[J].中华航海医学与高气压医学杂志,2009,17(5):113-115.
作者姓名:任旭荣  黄晨
作者单位:烟台山医院心内科,山东烟台,264001;烟台山医院骨肿瘤科,山东烟台,264001;
摘    要:Objective To investigate effect of hyperbaric oxygen treatment on infarct size of acute myocardial infarction and on the function of left ventricle in rats. Methods An acute myocardial infarction model was developed by using 50 male SD rats, which were randomly divided into 3 groups: the sham group(12 rats), the acute myocardial infarction group (AMI) (16 rats) and the HBO group(17 rats). Hyperbaric oxygen treatment was applied to the HBO group for a succession of 7 days. Infarct sizes, differences between systolic and diastolic pressures of the three groups and changes in cardiac hemodynamics (± dp/dtmax) were measured 7 days after treatment. Results When compared with that of the AMI group, infarct size and left ventricle function of the HBO group improved significantly (P < 0. 05). Conclusions Early administration of HBO could significantly reduce infarct size and improve left ventricle function of rats with AMI.

关 键 词:急性心肌梗死    高压氧治疗    左室功能    大鼠模型    

Effect of hyperbaric oxygen treatment on infarct size of acute myocardial infarction and on the function of left ventricle in rats
REN Xu-rong,HUANG Chen.Effect of hyperbaric oxygen treatment on infarct size of acute myocardial infarction and on the function of left ventricle in rats[J].Chinese Journal of Nautical Medicine and Hyperbaric Medicine,2009,17(5):113-115.
Authors:REN Xu-rong  HUANG Chen
Abstract:
Keywords:Acute myocardial infarctionHyperbaric oxygen treatmentLeft ventricle functionRat model
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