| 新辅助化疗对乳腺癌患者靶控输注异丙酚意识消失时半数有效效应室靶浓度的影响 |
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| 引用本文： | 何自静,李志红,胡永华,范志毅.新辅助化疗对乳腺癌患者靶控输注异丙酚意识消失时半数有效效应室靶浓度的影响[J].中华麻醉学杂志,2009,30(9):273-275. |
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| 作者姓名： | 何自静 李志红 胡永华 范志毅 |
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| 作者单位： | 北京肿瘤医院暨北京市肿瘤防治研究所麻醉科,恶性肿瘤发病机制及转化研究教育部重点实验室,北京大学临床肿瘤学院,100142; |
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| 摘 要： | Objective To investigate the effect of neoadjuvant chemotherapy on EC50 of propofol given by TCI which produces loss of consciousness (LOC) in breast cancer patients.Methods Ninety ASA Ⅰ or Ⅱ breast cancer patients aged 30-60 yr scheduled for elective surgery were allocated into 3 groups according to the chemotherapy the patients received (n=30 each):group Ⅰ control (group C) received no chemotherapy;group Ⅱ taxol and group Ⅲ adriamycine+cyclophosphamide+5-Fu.The patients were unpremedicated.The EC50 of propofol given by TCI was determined by up-and-down technique.The initial effect-site concentration (Ce) of propofol was 2.07μg/ml and the ratio between the 2 successive Ce was 1.09.Loss of response to verbal command and eyelash stimulation was used as sighs of LOC.The EC50 of propofol was calculated.Results The EC50 of propofol causing LOC was significantly lower in group Ⅱ and Ⅲ than in control group.There was no significant difference in the EC50 of propofol which produces LOC between group Ⅱ and Ⅲ.Conclusion The EC50 of propofol causing LOC in breast cancerpatients is decreased by adjuvant chemotherapy.
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| 关 键 词： | 化学疗法 辅助 二异丙酚 药物释放系统 剂量效应关系 药物 |
Effect of neoadjuvant chemotherapy on EC50 of propofol administered by TCI causing loss of consciousness in breast cancer patients |
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| HE Zi-jing,LI Zhi-hong,HU Yong-hua,FAN Zhi-yi.Effect of neoadjuvant chemotherapy on EC50 of propofol administered by TCI causing loss of consciousness in breast cancer patients[J].Chinese Journal of Anesthesilolgy,2009,30(9):273-275. |
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| Authors: | HE Zi-jing LI Zhi-hong HU Yong-hua FAN Zhi-yi |
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| Abstract: | |
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| Keywords: | Chemotherapy adjuvantPropofolDrug delivery systemsDose-response relationship drug |
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