99Tcm-MIBI与18F-FDG双核素同时采集法心肌显像检测存活心肌 |
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引用本文: | 郝骥,李东野,任少阳,张海男,李文华,潘德锋,徐通达,夏勇.99Tcm-MIBI与18F-FDG双核素同时采集法心肌显像检测存活心肌[J].中华核医学杂志,2009,29(4):328-330. |
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作者姓名: | 郝骥 李东野 任少阳 张海男 李文华 潘德锋 徐通达 夏勇 |
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作者单位: | 徐州医学院第二附属医院心内科;徐州医学院心血管病研究所、附属医院心内科,221006; |
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摘 要: | 目的 评价辨99Tcm-甲氧基异丁基异腈(MIBI)与18F-脱氧葡萄糖(FDG)双核素同时采集法心肌显像(DISA SPECT)检测存活心肌的临床价值.方法 21例经彩超检查证实存在左室壁节段运动障碍的冠心病患者,进行DISA SPECT、冠状动脉造影(CAG)及经皮冠状动脉介人治疗(PCI),对所有狭窄病变行完全血运重建术.参照美国超声心动图学会16节段划分法获得心肌各运动异常节段DISA SPECT图像,并对心肌存活情况进行判定.DISA SPECT图像用目测半定量法分析.术后1,3和6个月时复查心脏超声,以冠状动脉血运重建后室壁节段收缩功能改善为判断存活心肌的"金标准",根据诊断试验四格表评价DISA SPECT检测存活心肌的价值.结果 21例冠心病患者共获得符合条件的室壁运动异常节段156个,根据"金标准"判断其中105个为存活心肌,51个为非存活心肌,DISA SPECT检测存活心肌的灵敏度、特异性、阳性预测值、阴性预测值、准确性分别是93.3%(98/105)、82.4%(42/51)、91.6%(98/107)、85.7%(42/49)、89.7%(140/156).结论 DISASPECT目测半定量法检测存活心肌有较高的临床价值.
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关 键 词: | 冠状动脉疾病 体层摄影术 发射型计算机 单光子 脱氧葡萄糖 |
99Tcm-MIBI and 18F-FOG dual isotope simultaneous acquisition SPECT in determination of myocardial viability |
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Abstract: | Objective Viable myecardium is important to patients with coronary artery diseage.The obiecfive of this study was to evaluate the value of dual-isotope simultaneous acquisition SPECT(DISA SPECT)with 99Tcm-methoxyisobutylisonitrile (MIBI) and 18F-fluorodeoxyglueose (FDG) in detecting viable myocardium(VM).Methods Twenty-one patients with regional wall motion abnomudities(RWMA) based on routine echocardiography underwent DISA-SPECT,coronary angiography and percutaneous coronary intervention(PCI).Imaging and analysis of the left ventrieular myocardial perfusion status were performed according to the 16-segment models proposed by American Society of Echocardiography.The wall motion of every LV segment was observed by echocardiography after 1,3,6 months.The images of DISASPECT were analyzed semi-quantitatively.The"gold standard"for true viability was improvement of wall motion of the vertricular segment after PCI.Results There were 105 viable myocardial segments and 51 non-viable myocardial segments according to the"gold standard"criterion.The sensitivity,specificity.positive predict value,negative predict value and accuracy of DISA-SPECT in detecting viable myoeardium were 93.3%(98/105),82.4%(42/51),91.6%(98/107),85.7%(42/49),89.7%(140/156),respectively.Conclusion DISA-SPECT is a valuable technique to detect viable myocardium in patients with coronary artery disease. |
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Keywords: | MIBICoronary diseaseTomographyemission-computedsingle-photonMIBIDeoxyglucose |
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