糖尿病大鼠甲状腺组织降钙素免疫阳性滤泡旁细胞的变化

Objective To investigate the change of the parafollicular cells (C cell) in the thyroid of diabetes mellitus ( DM ) rats. Methods Fourteen male W rats were divided randomly into DM experiment group ( n = 8 )and normal (N) group ( n = 6). DM rats were sacrificed when 12 weeks after administration. Then the change of the number of calcitionin-positive C cells was investigated by immunohistochemistry method. Results Calcitionin-positive C cells in the thyroid of DM rats were round or ellips and were distributed separately or concentratively between the thyroid follicle and follicle epithelial cells. Under the high power lens, the C cell count of DM group was 37.400 ± 6. 533, which is more than the C cell count of N group ( 32.453 ± 4.5117 ). Under the lower power lens, The ratio of the positive reactive area and total area of the field of view in DM group was 0. 012 612 ±0. 0047 273, which was also higher than that of the N group(0.009 398 ±0.005 228). Both the distinctions had statistical significance.Conclusion The number of parafollicular cells increases in the thyroid of DM rats.

The change of calcitionin-positive parafolicular cells in the thyroid of diabetes mellitus rats