大剂量胞二磷胆碱治疗急性一氧化碳中毒迟发性脑病

目的 探讨运用大剂量胞二磷胆碱治疗急性一氧化碳中毒迟发性脑病(DEACMP)的临床疗效.方法 将124例DEACMP患者按随机数字表法分为治疗组68例,对照组56例.2组患者在常规治疗的基础上,对照组应用胞二磷胆碱注射液0.5 g配10%葡萄糖300 ml静脉滴注,1次/d,21 d为1个疗程,治疗组将对照组的胞二磷胆碱增至3.0 g.2组患者于入院第0、7、14、21天监测溶血磷脂酸和酸性磷脂酸浓度变化.结果 治疗组总有效率92.6%(63/68),对照组总有效率69.6%(39/56),2组疗效差异有统计学意义(P<0.05);治疗组治疗后溶血磷脂酸酸性磷脂酸浓度较治疗前均明显降低(P<0.01),而对照组变化不明显(均P>0.05).结论 大剂量胞二磷胆碱治疗DEACMP疗效高,不良反应少,值得临床推广.

Clinical study of megadose Cytidine Diphosphate Choline in treatment of delayed encephalopathy after acute carbon monoxide poisoning

Objective To investigate the clinical effect of megadose Cytidine Diphosphate Choline on de-layed encephalopathy caused by acute carbon monoxide poisoning. Methods One hundred and twenty-four patients with delayed encephalopathy resulting from acute carbon monoxide poisoning were randomly divided into treatment group (68 patients) and comparison group (56 patients). The comparison group was given Cytidine Diphosphate Choline Injection 0.5 g with glucose Injection 300 ml, once a day and 21 days as a period of treatment. The treat-ment group had Cytidine Diphosphate Choline 3.0 g, At the 0,7,14,21 days during therapy,the concentration of Ly-sophosphatidic(LPA) and Lpaalike phospholids (AP) were tested. Results Totally effective rate was 92.8% in the treatment group and 67.6% in the comparison group, showing a significant difference (P < 0.05). The concen-trations of LPA ad AP in treatment group were decreased after treatment (P < 0.01), but there was not significant differences in comparison group (P > 0.05). Conclusion Megadoso Cytidine Diphosphate Choline effectively de-lays encephalopathy after acute carbon monoxide poisoning.