Therapy of systemic fungal infections |
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Authors: | Wu Jashin J Pang Katie R Huang David B Tyring Stephen K |
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Institution: | Department of Dermatology, University of California, Irvine, CA,;Department of Dermatology, Wayne State University School of Medicine, Detroit, MI,;Division of Infectious Diseases, Department of Medicine, Baylor College of Medicine, Houston, TX,;Division of Infectious Diseases, Department of Medicine, University of Texas Health Science Center, Houston, TX,;University of Texas at Houston School of Public Health, University of Texas Health Science Center, Houston, TX, and;Department of Dermatology, University of Texas Health Science Center at Houston, Houston, TX, Center for Clinical Studies, Center for Clinical Studies, Houston, TX |
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Abstract: | The incidence of both community-acquired and nosocomial fungal infections has significantly increased over the past several decades. The major factors for this increase are a heightened use of antibiotics, a growing population of the elderly and of immunocompromised patients as a result of HIV, cancer, and organ transplantation. In this article, we will review the indications, efficacy, and safety of the polyenes, imidazoles, triazoles, and other systemic antifungals in development that are used for systemic fungal infections. |
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Keywords: | antifungal imidazoles polyenes triazoles |
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