硅烷化剂苯基二甲基氯硅烷的合成及应用 |
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引用本文: | 邓锋杰,陈萍华,温远庆,蒋华麟.硅烷化剂苯基二甲基氯硅烷的合成及应用[J].中国医药工业杂志,2006,37(4):225-226. |
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作者姓名: | 邓锋杰 陈萍华 温远庆 蒋华麟 |
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作者单位: | 1. 南昌大学化学系,江西,南昌,330047 2. 南昌航空工业学院环境化学系,江西,南昌,330034 |
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摘 要: | 用氯苯和二甲基二氯硅烷经格氏反应和取代反应制得硅烷化试剂苯基二甲基氯硅烷,总收率72%。将其应用于辛伐他汀的半合成,收率49%。
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关 键 词: | 苯基二甲基氯硅烷 辛伐他汀 半合成 应用 |
文章编号: | 1001-8255(2006)04-0225-02 |
收稿时间: | 2005-08-09 |
修稿时间: | 2005-08-09 |
Synthesis and Application of Phenyldimethylchlorosilane |
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Authors: | DENG Feng-Jie CHEN Ping-Hua WEN Yuan-Qing JIANG Hua-Lin |
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Institution: | 1. Dept. of Chemistry, Nanchang University, Nanchang 330047; 2. Dept. of Enviroment and Chemistry, Nanchang Aviation Industry University, Nanchang 330034 |
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Abstract: | Phenyldimethylchlorosilane was synthesized from chlorobenzene and dimethyldichlorosilane in 72 % yield. The title compound was applied to the semi-synthesis of simvastatin in 49% yield. |
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Keywords: | phenyldimethylchlorosilane simvastatin semi-synthesis application |
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