化瘀巴布膏体外透皮吸收研究

目的：研究促透皮吸收剂氮酮对化瘀巴布膏体外透皮吸收的影响。方法：采用改良Franz扩散池法，研究化瘀巴布膏中胡椒碱的体外透皮吸收特性，采用高效液相色谱法检测透过的胡椒碱，同时采用气相色谱法，以丁香酚为检测指标考察制剂稳定性。结果：经统计学分析，胡椒碱的体外渗透过程符合零级方程，并且试验过程中制剂基本稳定。结论：促透皮吸收剂氮酮可以促进药物的透皮吸收。

Study on in vitro percutaneous adsorption of Huayu Babu Sticking Plaster

Object To research the effect of laurocapram upon the percutaneous absorption of Huayu Babu Sticking Plaster (HBSP) in vitro. Methods The improved Franz diffusing cells were chosen to study percutaneous absorption of piperine from HBSP. The content of permeated piperine was determined by HPLC; while the content of augenol was determined by GC to inspect the stability of HBSP. Results The result showed that the process of penetrating of piperine in HBSP through skin could be in accordance with zero-grade releasing equation and HBSP was stable during the course of experiment. Conclusion Laurocapram could promote percutaneous absorption of piperine.