结构脂肪乳剂与物理混合的中/长链脂肪乳剂脂肪酸代谢比较研究

目的:比较结构脂肪乳剂(STG)与物理混合的中/长链脂肪乳剂(MCT/LCT)在人体内的脂肪酸代谢情况.方法:40例健康志愿者随机分为STG组和MCT/LCT组,每组20例.分别于早晨6h内匀速输注20%力文脂肪乳剂和20%力保肪宁脂肪乳剂1.0 g/(kg·次).并于给药前和给药后2、4、6和24 h留取血标本测定血...

The comparative study of structured triglyceride and physical mixed MCT/LCT on fatty acid metabolism in healthy subjects

Objective:The purpose of study was to compare fatty acid metabolism of structured triglyceride and physical mixed MCT/LCT in healthy subjects.Methods:Totally,40 healthy subjects were randomly allocated into STG group(n=20)and MCT/LCT group(n=20).The emulsions used in this study were 20% Structolipid and 20% Lipofundin respectively.6-h infusions of emulsion(1.0 g triglyceride/kg body wt) were from 6:00 Am to12:00 Am.Blood samples were taken before(time zero)and at timed intervals during(0-6 h)and after(24 h) emulsion infusion.Serum triglyceride concentrations and individual fatty acid profiles(C8∶0,C10∶0,C18∶2n-6,C18∶3n-3,C20∶4n-6) were analyzed.Results:The serum triglyceride concentrations was lower and more steady-state during STG infusion than during MCT/LCT infusion(P<0.05).C8∶0+ C10∶0 was lower and more steady-state in rates of hydrolysis during STG infusion than during MCT/LCT infusion(P<0.05,P<0.01).C18∶2n-6,C18∶3n-3,C20∶4n-6 were also lower(P<0.05,P<0.01).Conclusion:The fatty acid metabolism in structured triglyceride is better than in physical mixed MCT/LCT.