血浆PTX3检测在预测急腹症并发全身炎症反应综合征患者预后中的临床意义

目的：观察急腹症并发全身炎症反应综合征（systemic inflammatory response syndrome，SIRS）患者血浆正五聚素（pentraxin 3，PTX3）水平的动态变化，探讨PTX3在预测急腹症并发全身炎症反应综合征患者预后中的临床意义。方法：选取107例符合SIRS诊断的急腹症患者，分别于入院当日（0 d）及入院后1、5 d清晨采集空腹外周静脉血，用酶联免疫吸附法（ELISA）检测PTX3的血浆浓度，并设60例健康体检者为对照组予以比较。结果：107例急腹症并发全身炎症反应综合征患者的各监测点的PTX3水平均明显高于对照组，且并发症组患者血浆各监测点的PTX3水平均明显高于无并发症组，差异均有统计学意义（P〈0.05）。结论：急腹症并发SIRS时，PTX3表达增多，其升高程度与全身炎症反应综合征的严重程度及术后并发症发生密切相关。

Clinical Significance of Plasma PTX3 Detection in Predicting the Prognosis of Patients with Acute Abdomen Complicated with Systemic Inflammatory Response Syndrome

To observe the dynamic changes in serum cytokines levels of PTX3 and investigate the clinical significance of plasma PTX3 detection in predicting the prognosis of patients with acute abdomen complicated with systemic inflammatory response syndrome（SIRS）.Method：107 patients with acute abdomen complicated with systemic inflammatory response syndrome were selected,the peripheral venous blood were collected on the day of admission,and 1,5 days after admission respectively.The levels of pentraxin 3（PTX3）were detected by enzyme-linked immunosorbent assay,selected 60 healthy persons as control group,and compared with their results.Result：The levels of PTX3 in 107 patients with acute abdomen complicated with systemic inflammatory response syndrome at each monitoring point were significantly higher than those in the control group,and the levels of PTX3 in the complication group at each monitoring point were significantly higher than those in the no complication group,the differences were statistically significant（P〈0.05）. Conclusion：In acute abdomen patients combined with SIRS,the levels of PTX3 are increased.PTX3 elevated levels and systemic inflammatory response syndrome is closely related to the severity and postoperative complications.