| 沃替西汀的合成 |
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| 引用本文： | 任世言,孙钊,张春华. 沃替西汀的合成[J]. 齐鲁药事, 2014, 0(4): 241+243-241,243 |
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| 作者姓名： | 任世言 孙钊 张春华 |
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| 作者单位： | [1]山东大学药学院,山东济南250012 [2]东营鲁宁药业有限公司,山东东营257336 |
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| 摘 要： | 目的合成沃替西汀。方法以2,4-二甲基苯硫酚、2-溴碘苯和哌嗪为原料选用碘化亚铜、乙二醇、磷酸钾催化采用"一锅煮"法制得了沃替西汀。结果用价廉易得的催化剂合成了沃替西汀,收率85%。结论该工艺适合工业化生产。
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| 关 键 词： | 沃替西汀 合成 抗抑郁 |
Synthesis of vortioxetine |
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| REN Shi-yan,SUN Zhao,ZHANG Chun-hua. Synthesis of vortioxetine[J]. qilu pharmaceutical affairs, 2014, 0(4): 241+243-241,243 |
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| Authors: | REN Shi-yan SUN Zhao ZHANG Chun-hua |
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| Affiliation: | 1. School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China ;2. Dongying Luning Pharmaceutical Co. , Ltd. , Dongying 257336, China } |
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| Abstract: | Objective To synthesize of vortioxetine. Methods Vortioxetine was synthesized with the ＂ one - pot＂ method ,2,4 -dimethyl thiopheno1,2 -bromo -iodobenzene and piperazine as the raw material and cuprous iodide, ethylene glycol, potassium phosphate as the catalyst. Results Vortioxetine was synthesized with inexpensive and readily available catalyst and the total yield of the target compound was 85%. Conclusion The process was suitable for industrial produc- tion. |
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| Keywords: | Vortioxetine Synthesis Antidepressant |
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