痛情绪反应量化方法的探索 |
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引用本文: | 张肖怡,兰坤,冯晓璞,宋瑞瑞,张策,张宇.痛情绪反应量化方法的探索[J].现代保健,2014(18):45-48. |
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作者姓名: | 张肖怡 兰坤 冯晓璞 宋瑞瑞 张策 张宇 |
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作者单位: | [1]山西医科大学生理学系,山西太原030001 [2]山西医科大学医学影像系 ,山西太原030001 [3]山西医科大学第一临床医学院,山西太原030001 |
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基金项目: | 国家自然科学基金资助项目(81371254) |
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摘 要: | 目的:在经典的formalin诱导的条件位置回避模型的基础上,结合本实验室条件探索一种新的痛情绪测量。方法:完全弗氏佐剂(CFA)诱导的条件性位置回避。方法:雄性SD大鼠左侧足底皮下注射完全弗氏佐剂,建立条件性位置回避(CPA)模型。结果:SD大鼠足底皮下注射CFA会引起持续的炎性疼痛,可以产生稳定的条件性位置回避。足底注射生理盐水(NS)组和空白对照(naive)组不能产生条件性位置回避。结论:CFA诱导的CPA模型可以作为痛情绪量化的一种方法。
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关 键 词: | 完全弗氏佐剂 条件性位置回避 持续性炎性痛 痛情绪 大鼠 |
Exploration of Pain Emotional Response Quantization Method |
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Institution: | ZHANG Xiao-yi, LAN Kun, FENG Xiao- pu, et al (Department of Physiology in Shanxi Medical University, Taiyuan 030001, China) |
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Abstract: | To explore a new method for measuring pain mood:Complete Freund’s adjuvant(CFA)-induced CPA model to measure affective dimension of pain,based on the classical formalin of conditioned place avoidance (F-CPA)model and our laboratory conditions.Method:The male Sprague-Dawley(SD)rats’left hind paw were given hypodermic injection the CFA,successfully established CFA induced CPA model in rat.Result:Compared with the injection of normal saline(NS)group and blank control group,intra-plantar injection of CFA induced persistence inflammatory pain and stabile CPA.Conclusion:CFA-induced CPA model in rat can be a method of reflecting pain-related negative emotion. |
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Keywords: | Complete Freund’s adjuvant Conditioned place avoidance Persistence inflammatory pain Affective dimension of pain Rat |
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