血栓前状态标志物在2型糖尿病早期动脉硬化中的应用

目的：探讨血栓前状态标志物在2型糖尿病早期动脉硬化中的作用。方法：结合糖尿病及动脉硬化检测结果将60例患者分成正常对照组、糖尿病非动脉硬化组、糖尿病动脉硬化组，分别检测血栓前状态标志物TG、TC、LDL、HDL、WBC、血小板聚集率FIB、DD、PC、PS和血小板聚集率。结果：糖尿病非动脉硬化组、糖尿病动脉硬化组中TG、WBC、FIB、VWF与正常组比较差异均有统计学意义（P〈0.05），糖尿病非动脉硬化组、糖尿病动脉硬化组中BMI、TCH、HDL、LDL、DD、PLT、PS、PC与正常组比较差异均无统计学意义（P〉0.05）。结论：血脂代谢紊乱、慢性炎症刺激、高凝等血栓前状态的危险因素在糖尿病的发生、发展中起着重要的作用，然而是否在糖尿病早期动脉硬化中起作用有待进一步的研究。

Application of Pre-thrombus Status Markers of Early Atherosclerosis in Type 2 Diabetes

To discuss the role of pre-thrombus status markers in early atherosclerosis in TD2M. Method：Sixty subjects were divided into three groups：normal control,diabetes without arteriosclerosis,diabetes with arteriosclerosis by combining with diabetes and atherosclerosis dates.The pre-thrombus status markers of TG,TC,LDL, HDL,WBC,FIB,DD,PC,PS,Platelet aggregation rate were respectively detected.Result：Compared with the normal group,there were significant differences of TG,WBC,FIB,VWF in diabetes with atherosclerosis group and diabetes without atherosclerosis group（P〈0.05）.Compared with the normal group,there were no differences of BMI, TCH,HDL,LDL,DD,PLT,PS,PC in diabetes with atherosclerosis group and diabetes without atherosclerosis group （P〉0.05）.Conclusion：The risk factors of pre-thrombus status,Lipid metabolism disorder,chronic inflammatory stimulation,high condensation play key roles in the occurrence and development of diabetes. However,whether pre-thrombus status markers plays a role in diabetes early atherosclerosis and has yet to be confirmed by further studies.