| 无义介导的mRNA降解与肿瘤 |
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| 引用本文： | 林敏,谢海龙,苏琦.无义介导的mRNA降解与肿瘤[J].国际病理科学与临床杂志,2006,26(4):4-294. |
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| 作者姓名： | 林敏 谢海龙 苏琦 |
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| 作者单位： | 南华大学肿瘤研究所,湖南,衡阳,421001 |
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| 摘 要： | 无义介导的mRNA降解（nonsense-mediated mRNA decay，NMD）能够选择性降解含有翻译提前终止密码子(premature translation termination condon, PTC)的mRNA，从而防止对机体有害的截短蛋白(truncated proteins)的产生，它是真核生物中广泛存在的一种高度保守的有效的监督机制。 NMD与肿瘤发生发展过程中的基因突变有密切关系。
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| 关 键 词： | 无义介导的mRNA降解 翻译提前终止密码子 肿瘤 |
| 文章编号： | 1673-2588(2006)04-0291-03 |
| 收稿时间： | 2006-4-25 |
| 修稿时间： | 2006年4月25日 |
Nonsense-mediated mRNA decay and tumor |
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| LIN Min,XIE Hai-long,SU Qi.Nonsense-mediated mRNA decay and tumor[J].Journal of International Pathology and Clinical Medicine,2006,26(4):4-294. |
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| Authors: | LIN Min XIE Hai-long SU Qi |
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| Institution: | Cancer Institute of Nanhua University, Hengyang Hunan 421001, China |
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| Abstract: | In eukaryotic cells,nonsense-mediated mRNA decay(NMD) is an evolutionarily well-conserved and effective mRNA surveillance mechanism that can selectively degrade mRNAs with premature translation termination codons(PTC) and protect cells from the potentially deleterious effects of truncated proteins.NMD is intimately associated with gene mutation in the occurence and development of human cancer. |
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| Keywords: | nonsense-mediated mRNA decay premature translation termination codons tumor |
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