Differentiation of Stem Cells into Insulin-Producing Cells: Current Status and Challenges |
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Authors: | Marta Pokrywczynska Sandra Krzyzanowska Arkadiusz Jundzill Jan Adamowicz Tomasz Drewa |
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Affiliation: | 1. Department of Tissue Engineering, Ludwik Rydygier Medical College in Bydgoszcz, Nicolaus Copernicus University in Torun, Karlowicza 24, 85-092, Bydgoszcz, Poland 2. Department of Urology, Nicolaus Copernicus Hospital, Torun, Poland
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Abstract: | Diabetes mellitus is one of the most serious public health challenges of the twenty-first century. Allogenic islet transplantation is an efficient therapy for type 1 diabetes. However, immune rejection, side effects of immunosuppressive treatment as well as lack of sufficient donor organs limits its potential. In recent years, several promising approaches for generation of new pancreatic β cells have been developed. This review provides an overview of current status of pancreatic and extra-pancreatic stem cells differentiation into insulin-producing cells and the possible application of these cells for diabetes treatment. The PubMed database was searched for English language articles published between 2001 and 2012, using the keyword combinations: diabetes mellitus, differentiation, insulin-producing cells, stem cells. |
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