| rAd—p53瘤内注射前后鼻咽癌原发灶p53、p21WAF1蛋白的表达及意义 |
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| 引用本文： | 黄波,司勇锋,兰桂萍,韦海明,覃扬达,孙金杰,何承诚. rAd—p53瘤内注射前后鼻咽癌原发灶p53、p21WAF1蛋白的表达及意义[J]. 广西医学, 2011, 33(11): 1397-1400 |
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| 作者姓名： | 黄波 司勇锋 兰桂萍 韦海明 覃扬达 孙金杰 何承诚 |
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| 作者单位： | 1. 广西壮族自治区人民医院耳鼻咽喉头颈肿瘤科,南宁市,530021
2. 广西壮族自治区人民医院病理科,南宁市,530021 |
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| 基金项目： | 广西医药卫生科学研究基金资助项目 |
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| 摘 要： | 目的探讨重组人p53腺病毒（rAd—p53）瘤内注射前后的鼻咽癌原发灶中p53蛋白、p21WAF1蛋白的表达情况及其意义。方法51例中晚期鼻咽癌的患者随机分为两组，治疗组27例rAd—p53瘤内注射＋同步放化疗，对照组24例同步放化疗。分别收集临床资料及rAd—p53瘤内注射前后鼻咽部瘤体组织标本。采用免疫组化二步法检测鼻咽癌原发灶组织标本中p53蛋白、p21WAF1蛋白的表达情况。结果治疗组治疗前、后鼻咽癌原发灶p53蛋白和p21WAF1蛋白阳性表达率分别为33．33．0％和33．3％、62．96％和77．77％，p53蛋白和p21WAF1蛋白阳性表达率在治疗后均明显提高，治疗前后比较差异均有统计学意义（P均〈0．05）。对照组治疗前、后鼻咽癌原发灶p53蛋白和p21WAF1蛋白的阳性表达率分别为40．74％和37．5％、51．58％和50．0％，两者治疗后也有所增高，但治疗前后比较差异均无统计学意义（P均〉0．05）。结论rAd-p53瘤内注射后，鼻咽癌原发灶p53蛋白表达增加进而导致p21WAF1蛋白表达增加，可能是其治疗鼻咽癌的作用机制之一。
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| 关 键 词： | 鼻咽癌 rAd—p53 p53蛋白 p21WAF1蛋白 |
Expression of p53,P21waf1 Protein in Nasopharyngeal Carcinoma Primary Site after rAd-p53 Intratumoral Injection and its Significance |
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| HUANG Bo,SI Yong-feng,LAN Gui-ping,WEI Hai-ming,QIN Yang-da,SUN Jin-jie,He Cheng-cheng. Expression of p53,P21waf1 Protein in Nasopharyngeal Carcinoma Primary Site after rAd-p53 Intratumoral Injection and its Significance[J]. Guangxi Medical Journal, 2011, 33(11): 1397-1400 |
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| Authors: | HUANG Bo SI Yong-feng LAN Gui-ping WEI Hai-ming QIN Yang-da SUN Jin-jie He Cheng-cheng |
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| Affiliation: | HUANG Bo1,SI Yong-feng1,LAN Gui-ping1,WEI Hai-ming2,QIN Yang-da1,SUN Jin-jie1,He Cheng-cheng1(1 Department of Otolaryngology Head and Neck Oncology,2 Department of Pathology,People's Hospital of Guangxi Zhuang Autonomous Region,Nanning 530021,China) |
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| Abstract: | Objective To investigate the expression of p53 protein and p21WAF1 protein when the recombinant human p53 adenovirus(rAd-p53)before and after nasopharyngeal primary site intratumoral injection,and to investigate its significance.Methods 51 patients who were diagnosed with advanced nasopharyngeal carcinoma were randomly divided into two groups,treatment group(27 cases)were treated with rAd-p53 intratumoral injection and concurrent chemo-radiotherapy,and control group(24 cases)were treated with concurrent che... |
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| Keywords: | rAd-p53 |
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