国产异晶形哌吡氮平预防和血平性溃疡的实验研究

应用大鼠实验性利血平溃疡模型观察了国产异晶形哌吡氮平的抗溃疡作用,并比较了国产异晶形哌吡氮平与哌吡氮平的抗利血平性溃疡作用强度。结果表明:国产异晶形哌吡氮平对大鼠利血平性胃溃疡有明显预防作用,给大鼠sc或ig国产异晶形哌吡氮平均有明显预防利血平性溃疡作用。国产异晶形哌吡氮平与哌吡氮平sc时,二者的抗溃疡作用无明显差异;国产异晶形哌吡氮平与哌吡氮平ig时,前者的抗溃疡作用明显低于后者。

ONE EXPERIMENTAL STUDY OF PREVENTIVE EFFECT OF CHINA-MADE ISOCRYSTAL PIRENZEPINE ON RESERPINE-IN-DUCED ULCER

Effect of China-made isocrystal pirenzepine ( IPRZ ) on experimental ulcer produced by reserpine in rats was studied & the antiulcer effect of China-made IPRZ was compared with that of China-made PRZ. Our results showed that China-made IPRZ given by either sc ( 25-100 mg/kg ) or ig ( 25-100 mg/kg ) exerted a marked antiulcer effect on reserpine-induced gastric ulcer in rats.The antiulcer effect was increased with the increase of dose of China-made IPRZ. When China-made IPRZ was given by sc, its antiulcer effect was as potent as China-made PRZ, but when it was given by ig, its antiulcer effect was lower than China-made PRZ .This result suggest that the bioavailabili-ty of China-made IPRZ given by ig was lower than China-made PRZ.