| CML的基因沉默与过继免疫治疗的研究进展 |
| |
| 引用本文： | 高炳华,王新生.CML的基因沉默与过继免疫治疗的研究进展[J].军事医学科学院院刊,2013(11):870-872. |
| |
| 作者姓名： | 高炳华 王新生 |
| |
| 作者单位： | [1]河北北方学院附属第一医院血液科,河北张家口075000 [2]河北北方学院第一临床医学院,河北张家口075000 |
| |
| 基金项目： | 河北省科技支撑计划资助项目（11276103D-10） |
| |
| 摘 要： | 慢性粒细胞白血病是一种造血干细胞的恶性克隆增殖性疾病，以分子生物学、免疫学、细胞生物学为基础的治疗手段成为新的研究方向。 siRNA介导的基因沉默通过降解靶标mRNA，miRNA介导的基因沉默通过使靶mRNA失去稳定性以减少蛋白质的生成，从而提高靶向治疗药物的治疗效果。过继免疫治疗是通过将CIK、NK等免疫活性细胞注入肿瘤宿主体内，提高机体免疫力，与靶向治疗药物协同提升治疗效果。其理论基础、分子机制、临床疗效等还需进一步深入研究。
|
| 关 键 词： | 慢性粒细胞白血病 免疫疗法 过继 基因沉默 siRNA 小分子干扰 微RNAs |
Advance in research on CML therapy by gene silence and adoptive cellular immunotherapy |
| |
| GAO Bing-hua,WANG Xin-sheng.Advance in research on CML therapy by gene silence and adoptive cellular immunotherapy[J].Bulletin of the Academy of Military Medical Sciences,2013(11):870-872. |
| |
| Authors: | GAO Bing-hua WANG Xin-sheng |
| |
| Institution: | 1. Department of Hematology, the First Attached Hospital of Hebei North University, Zhangjiakou, Hebei 075000, China; 2. The First Clinical College of Hebei North University, Zhangjiakou, Hebei 075000, China) |
| |
| Abstract: | Chronic myeloid leukemia is a kind of malignant cloning hyperplastic disease of hematopoietic stem cell .The treatments based on molecular biological and immunological techniques will become the new therapies .Gene silence can improve the effects of molecular targeted therapeutic drugs through two ways： one is the target mRNA can be digested by siRNA and the other is target gene lose the stability and reduce the generation of protein mediated by miRNA .Adoptive cel-lular immunotherapy is a treatment method through injecting immunocompetent cells such as CIK , NK, etc into the body of cancerous person .This can improve the immunity of body and the effects of molecular targeted therapeutic drugs .The fur-ther study about basic theory , molecular mechanism and clinical effects will be continued . |
| |
| Keywords: | chronic myeloid leukemia immunotherapy adoptive gene silencing RNA smallinterfering miRNA |
| 本文献已被 维普 等数据库收录！ |
