妊娠期高血压疾病并发肾病综合征对母婴的影响

目的 分析妊娠期高血压疾病并发肾病综合征的临床特征及其与不良妊娠结局的关系.方法 回顾性分析本院1997年1月互2008年1月35例妊娠期合并肾病综合征(肾病组)和121例未合并肾病综合征(对照组)的妊娠期高血压疾病重度子痫前期患者的临床资料,比较两组血压、生化指标和母婴并发症.结果 肾病组发病孕周早,24 h尿蛋白定量、低蛋白血症、肾功能受损、母婴并发症显著高于对照组(P<0.01),肾痛组围生儿死亡率高于对照组,差异有统计学意义(P<0.05).结论 妊娠期肾病综合征发病孕周早,对母婴影响大,早诊断、综合治疗和适时终止妊娠可减少妊娠期母婴并发症,改善母婴预后.

Influence of Nephrotic Syndrome with Pregnancy Induced Hypertension on Pregnancy Outcomes

Aim To investigate the clinical features of nephrotic syndrome with pregnancy induced hypertension (NSP) and the relationship between NSP and poor pregnancy outcomes. Methods Clinical data of 35 cases with NSP (NSP group) and 121 cases with other severe pre-eclampsia (control group) were analyzed retrospectively in this hospital during January 1997 to January 2008. Blood pressure,biochemical indicators,birth weight and maternal and fetal complications were compared between the two groups. Results The incidence of NSP was 0.04%. Those in NSP group were taken bad earlier than those in control group in gestation. The incidence of protein-uria in 24-hour,low albumin-emia,abdominal water,renal-function lesion,premature and maternity and fetus complication in NSP group were higher than that in control group significantly (P<0.01),and perinatal mortality in NSP group was higher than that in control group (P<0.05). Conclusions NSP often occurs early in gestation. The perinatal prognosis is poor. Early diagnosis,comprehensive therapy and pregnancy termination in time may decrease the incidence of maternity-fetus complication and improve maternal-fetal prognosis.