| 单克隆抗体介导异种巨噬细胞对肿瘤细胞的杀伤作用 |
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| 引用本文： | 吕同德,于兰,颉东旭. 单克隆抗体介导异种巨噬细胞对肿瘤细胞的杀伤作用[J]. 细胞与分子免疫学杂志, 1992, 0(4) |
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| 作者姓名： | 吕同德 于兰 颉东旭 |
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| 作者单位： | 兰州军区总医院实验科，兰州军区总医院实验科，兰州军区总医院实验科 兰州 730050，兰州 730050，兰州 730050 |
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| 摘 要： | 本文研究了抗人胃癌McAb ID1-2在体外介导的小鼠腹腔巨噬细胞对肾癌肿瘤细胞(GGC-8140)的杀伤作用。结果表明,在McAb的介导下异种巨噬细胞杀伤靶细胞的作用明显增加。McAb可能是通过其FC段与巨噬细胞上的FC受体结合而增强对靶细胞的杀伤作用参与抗肿瘤的免疫应答。
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| 关 键 词： | 抗体 单克隆 巨噬细胞 肿瘤细胞 细胞毒作用 |
Monoclonal Antibody-mediated Cytotoxicity to Tumor Cells by Heterogenous Macrophages |
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| Lu Tongde,et al.. Monoclonal Antibody-mediated Cytotoxicity to Tumor Cells by Heterogenous Macrophages[J]. Chinese journal of cellular and molecular immunology, 1992, 0(4) |
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| Authors: | Lu Tongde et al. |
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| Abstract: | In the present experiment, the authors investigated the effect of monoclonal antibody (GMG1:1D1-2 ) against human gastric cancer on the in vitro cytotoxicity to gastric cancer cells GGC-8140 by murine peritoneal macrophages.The results showed that opsonization of target cells by monoclonal antibody 1D1- 2 markedly enhanced the percentage of cytotoxicity of heterogenous macrophage. HE staining revealed that the target cells were wrapped up and lysed and there was a significant decrease in the number of target cells. These findings suggested that monoclonal antibody may take part in antitumor immune responses by mediating cytotoxicity of heterogenous macrophages. |
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| Keywords: | antibody monoclonal macrophage tumor cell cytotoxicity |
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