海洛因对大鼠肝功能血浆酶学的影响

目的：研究海洛因依赖大鼠肝功能的变化。方法：采用逐渐递增剂量法腹腔注射海洛因，建立海洛因依赖及戒断大鼠模型，50只建模成功Wistar大鼠随机分成对照组、给药3 d组、给药9 d组、戒断3 d组及戒断9 d组，检测各组大鼠血液生化指标天门冬氨酸氨基移换酶（AST）、丙氨酸氨基移换酶（ALT）及γ-谷氨酰基移换酶（GGT）。结果：与对照组比较，给药3 d组ALT的含量明显下降（P<0.05），给药9 d组ALT的含量下降更为显著（P<0.01），戒断3 d组ALT的含量上升显著（P<0.01）;给药9 d组GGT的含量显著下降（P<0.01）。与给药9 d组相比，戒断 3 d组AST的血浆含量显著升高（P<0.01）；戒断3 d、9 d组的ALT血浆含量均显著升高（P<0.01）；戒断3 d组血浆GGT含量明显升高（P<0.05），戒断9 d组血浆GGT含量升高更为显著（P<0.01）。结论： 海洛因对肝功能的损害有延迟性及持续性，且不能在停药后立即消除。

Effect of heroin on enzyme in plasma of liver function in rats

Objective To investigate the changes of liver function in heroin dependent rats.Methods Using intraperitoneal injection with increasing doses to establish rat models of heroin administration and withdrawal.50 Wistar rats were randomly divided into five groups: control,3 d administration group,9 d administration group,3 d withdrawal group and 9 d withdrawal group.The levels of aspartate aminotransferase(AST),alanine aminotransferase(ALT) and γ-glutamyl transpeptidase(GGT) in plasma were tested.Results Compared with control group,the level of ALT in 3 d withdrawal group decreased significantly(P<0.01),the level of ALT in 3 d administration group decreased significantly(P<0.05),the level of ALT in 9 d administration group decreased even significantly(P<0.01),the level of ALT in 3 d withdrawal group increased apparently(P<0.01);and the level of GGT in 9 d administration group decreased apparently.Compared with 9 d administration group,the level of AST in 3 d withdrawal group increased apparently(P<0.01),the levels of ALT both in 3 d and 9 d withdrawal groups increased apparently(P<0.01),the level of GGT in 3 d withdrawal group increased apparently(P<0.05),and the level of GGT in 9 d withdrawal group increased even apparently(P<0.01).Conclusion The heroin has detention and durative damage to the liver function,and can't be eliminated immediately after drug withdrawal.