| 吡格列酮对初诊2型糖尿病患者血脂水平的影响及临床意义 |
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| 引用本文： | 杨杨,戚筠,谢军,叶跃青,刘志平,邢晓磊,姚春红,白如君,邱宇珍. 吡格列酮对初诊2型糖尿病患者血脂水平的影响及临床意义[J]. 微循环学杂志, 2011, 21(1): 30-31,34,80,84 |
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| 作者姓名： | 杨杨 戚筠 谢军 叶跃青 刘志平 邢晓磊 姚春红 白如君 邱宇珍 |
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| 作者单位： | 武汉科技大学附属天佑医院内分泌,武汉,430064 |
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| 基金项目： | 湖北省教育厅科研项目，湖北省教育厅教学项目，武汉科技大学引进人才科研启动基金 |
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| 摘 要： | 目的:观察吡格列酮对初诊2型糖尿病(T2DM)患者血脂水平的影响。方法:98例初诊T2DM患者随机分为两组:治疗组,用吡格列酮加二甲双胍治疗;对照组,用安慰剂加二甲双胍治疗,均治疗12周,观察治疗前后两组血糖指标空腹血糖(FBG)、餐后2h血糖(2hPG)、糖化血红蛋白(HbA1c)及血脂指标甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)的变化。结果:治疗后,两组FBG、2hPG、HbA1c均明显下降(P<0.05)。治疗组患者TG、TC、LDL-C水平明显下降(P<0.05),HDL-C明显升高(P<0.05);对照组TG和LDL-C无明显改变,TC明显下降,HDL-C明显升高,但是幅度均低于治疗组(P<0.05)。结论:吡格列酮可提高对初诊T2DM患者血脂代谢紊乱的改善作用,吡格列酮和二甲双胍合用的降血糖效果优于单用二甲双胍。
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| 关 键 词： | 吡格列酮 2型糖尿病 血脂 |
Significance of Pioglitazone on Blood Lipids Spectrum of Type 2 Diabetes |
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| Yang Yang,Qi Yun,Xie Jun,et al/. Significance of Pioglitazone on Blood Lipids Spectrum of Type 2 Diabetes[J]. Chinese Journal of Microcirculation, 2011, 21(1): 30-31,34,80,84 |
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| Authors: | Yang Yang Qi Yun Xie Jun et al/ |
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| Affiliation: | Yang Yang,Qi Yun,Xie Jun,et al/Department of Endocrinology,Affiliated Tianyou Hospital of Wuhan University of Science and Technology. Wuhan 430064 |
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| Abstract: | Objective:To observe the effect of pioglitazone on blood lipids in preliminary diagnosis type 2 diabetes mellitus(T2DM). Method:98 preliminary diagnosis T2DM patients were divided into two groups randomly,and therapy group was treatment with pioglitazone and metformin,and control group was with placebo and metformin for 12 weeks,so that the level of blood glucose and blood lipids were detected before and after therapy.Results:Level of FBG,2hPG and HbA1c were lower in two groups after therapy(P<0.05),and the... |
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| Keywords: | Pioglitazone Type 2 diabetes mellitus (T2DM) Blood lipids |
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