阿奇霉素治疗小儿支原体肺炎疗效之变化

目的观察阿奇霉素临床疗效的变化。方法选择注射用阿奇霉素治疗的支原体肺炎患儿,2006年及2009年分别为33例和42例,阿奇霉素剂量5～10mg/(kg.d),一日一次,第一疗程用5天停3天,第二疗程用3天停3天,分析比较两组疗效。结果 2006年有效32例(97.0%),2009年有效33例(78.5%),两组比较疗效有统计学意义。结论肺炎支原体对阿奇霉素的临床耐药现象上升明显。

Clinical effect changes of azithromycin in treatment of children with mycoplasma pneumonia

Objective To observe the clinical efficiency changes of azithromycin and pay attention to the problem about the resistance of mycoplasma pneumoniae to azithromycin.Methods The children who were infected by mycoplasma pneumoniae were chosen and received the therapy of azithromycin in 2006 and in 2009.There were 33 cases in 2006 and 42 cases in 2009,azithromycin dose 5~10 mg/（kg·d）,once a day,the first course of the treatment continued for 5 days and stopped for 3 days,the second course of the treatment continued for 3 days and stopped for 3 days.The two groups＇ efficacy was analyzed.Results 32 cases were effective in 2006（97.0%）and 33 cases were effective in 2009（78.5%）,the two groups was statistically significant.Conclusion Clinical resistance of mycoplasma pneumoniae to azithromycin increases significantly.