Brief Report: Brain Activation to Social Words in a Sedated Child with Autism |
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| Authors: | Dennis P. Carmody Rosanne Moreno Audrey E. Mars Kapila Seshadri George H. Lambert Michael Lewis |
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| Affiliation: | (1) Institute for the Study of Child Development, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, 97 Paterson Street, New Brunswick, NJ 08903-0019, USA;(2) Department of Pediatrics, Division of Child Neurology and Neurodevelopmental Disabilities, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, New Brunswick, NJ, USA;(3) Center for Childhood Neurotoxicology and Exposure Assessment, Division of Pediatric Pharmacology and Toxicology, Pediatric Clinical Research Center, Department of Pediatrics, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, New Brunswick, NJ, USA;(4) Institute for the Study of Child Development, Department of Pediatrics, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, New Brunswick, NJ, USA |
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| Abstract: | A functional magnetic resonance imaging (fMRI) study was performed on a 4-year-old girl with autism. While sedated, she listened to three utterances (numbers, hello, her own first name) played through headphones. Based on analyses of the fMRI data, the amount of total brain activation varied with the content of the utterance. The greatest volume of overall activation was in response to numbers, followed by the word ‘hello’, with the least activation to her name. Frontal cortex activation was greatest in response to her name, with less activation for numbers, and the least for the word ‘hello.’ These findings indicate that fMRI can identify and quantify the brain regions that are activated in response to words in children with autism under sedation. |
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| Keywords: | Autism fMRI Self-awareness |
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