| 妊娠期糖尿病母婴血清及胎盘中内脂素表达的研究 |
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| 引用本文： | 张天峰,唐平,刘杰波,郭广洲,陈永平.妊娠期糖尿病母婴血清及胎盘中内脂素表达的研究[J].实用全科医学,2011(7):1016-1017,1045. |
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| 作者姓名： | 张天峰 唐平 刘杰波 郭广洲 陈永平 |
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| 作者单位： | 广东省深圳市罗湖区人民医院妇产科;广东省深圳市罗湖区人民医院内分泌科;广东省深圳市罗湖区人民医院新生儿科;广东省深圳市罗湖区人民医院检验科;广东省深圳市罗湖区人民医院病理科; |
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| 基金项目： | 广东省深圳市科技局科研项目(201003440) |
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| 摘 要： | 目的探讨妊娠期糖尿病母婴血清及胎盘中内脂素（visfatin）的表达与胎儿生长发育的关系。方法采用酶联免疫吸附法及放免法分别测定30例妊娠期糖尿病（gestational diabetes mellitus,GDM）及30例正常孕妇母婴血清内脂素及胰岛素水平,同时测定空腹血糖、母婴体重及身高、计算胰岛素抵抗指数（HOMA-IR）及体重指数。采用逆转录-聚合酶链反应（RT-PCR）及免疫组织化学方法,检测两组胎盘内脂素基因mRNA的表达及蛋白的表达水平。结果①GDM组血清visfatin、FBG、FIN、HOMA-IR、BMI水平显著高于对照组（P〈0.05）。②GDM组新生儿出生体重、RI、脐血visfatin、脐血血糖、脐血胰岛素及HOMA-IR水平显著高于对照组（P〈0.05）。③GDM组胎盘组织visfatin mRNA及蛋白表达水平显著高于对照组（P〈0.05）。结论 GDM孕妇血清及胎盘内脂素水平的升高可能参与了GDM的发生发展以及胎儿的宫内发育的调节。
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| 关 键 词： | 内脂素 妊娠期糖尿病 胰岛素抵抗 胎盘 |
Expression of Visfatin in Placenta and Serum of Fetuses and Mothers with Gestational Diabetes Mellitus |
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| ZHANG Tian-feng,TANG Ping,LIU Jie-bo,et al..Expression of Visfatin in Placenta and Serum of Fetuses and Mothers with Gestational Diabetes Mellitus[J].Applied Journal Of General Practice,2011(7):1016-1017,1045. |
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| Authors: | ZHANG Tian-feng TANG Ping LIU Jie-bo |
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| Institution: | ZHANG Tian-feng,TANG Ping,LIU Jie-bo,et al.Department of Obstetrics and Gynecology,Luohu People's Hospital,Shenzhen 518001,Guangdong,China |
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| Abstract: | Objective To investigate the relationship between intrauterine growth of fetuses and the expression of visfatin in placenta and serum of fetuses and mother with gestational diabetes mellitus(GDM).Methods The levels of serum visfatin,fasting blood glucose(FBG) and fasting insulin(FIN) were measured severally by Enzyme-linked immunosorbent assay(ELISA),glucose oxidase,radioimmunity assay.The insulin resistance index(HOMA-IR) was calculated.The expression of visfatin mRNA and protein were separately determined... |
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| Keywords: | Visfatin Gestational diabetes mellitus Insulin resistance Placenta |
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