| VEGF—C及其受体VEGFR-3在骨肉瘤中的表达及临床意义 |
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| 引用本文： | 李永昊,肖玉周,汪万英.VEGF—C及其受体VEGFR-3在骨肉瘤中的表达及临床意义[J].实用全科医学,2011(8):1187-1189,F0003. |
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| 作者姓名： | 李永昊 肖玉周 汪万英 |
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| 作者单位： | 蚌埠医学院第一附属医院骨科;蚌埠医学院中心实验室; |
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| 摘 要： | 目的探讨血管内皮细胞生长因子-C（VEGF-C）与血管内皮细胞生长因子受体VEGFR-3（Flt4），在骨肿瘤．中的表达及临床意义。方法应用免疫组化和原位杂交方法检测105例骨肿瘤组织中的VEGF-C、Fh4的表达，并对其中85例骨肉瘤主要临床资料、病理分级及I临床相关参数进行比较，用X2检验进行统计学处理。结果骨肉瘤中VEGF-C、Flt4的蛋白及mRNA阳性表达率明显高于骨软骨瘤阳性表达率（P〈0．01）。在骨肉瘤临床分期中1Ib期、Ⅲ期明显高于I期、1Ia期（P〈0．01），并随着病理分级恶性程度增高而显著增加（P〈0.01）。且在软组织浸润和转移组中VEGF-C、Flt4蛋白及mRNA的阳性表达率明显高于非浸润和非转移组（P〈0．01）。结论VEGF-C、Flt4的蛋白及mRNA在骨肉瘤中不同程度异常表达与肿瘤的临床分期、病理分级和浸润、转移呈正相关，提示VEGF—C、F1t4的蛋白及其mRNA高表达尤其在骨肉瘤的浸润转移过程中发挥重要作用。
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| 关 键 词： | VEGF—C VEGFR-3 骨肿瘤 免疫组化 原位杂交 |
Expression of VEGF-C and VEGFR-3 in Osteosarcoma and its Clinical Significance |
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| LI Yong-hao,XIAO Yu-zhou,WANG Wan-ying.Expression of VEGF-C and VEGFR-3 in Osteosarcoma and its Clinical Significance[J].Applied Journal Of General Practice,2011(8):1187-1189,F0003. |
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| Authors: | LI Yong-hao XIAO Yu-zhou WANG Wan-ying |
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| Institution: | LI Yong-hao,XIAO Yu-zhou,WANG Wan-ying.Department of Orthopaedics,the First Affiliated Hospital of Bengbu College,Bengbu 233004,Anhui,China |
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| Abstract: | Objective To investigate the expression of vascular endothelial growth factor-C(VEGF-C) and vascular endothelial growth factor receptor VEGFR-3(Flt4) in bone tumors and its clinical significance.Methods The expression of VEGF-C and Flt4 in 105 cases of bone tumor tissue were detected by immunohistochemistry and in situ hybridization.The main clinical features,histological grade and clinical parameters of 85 cases of osteosarcoma were compared with chi-square test.Results The protein and mRNA expression of V... |
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| Keywords: | VEGF-C VEGFR-3 Bone tumor Immunohistochemistry In situ hybridization |
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