| 高龄心房颤动患者华法林治疗的效果与风险观察 |
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| 引用本文： | 单黎丽. 高龄心房颤动患者华法林治疗的效果与风险观察[J]. 实用全科医学, 2011, 0(8): 1205-1206 |
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| 作者姓名： | 单黎丽 |
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| 作者单位： | 安徽省阜阳市人民医院老年科; |
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| 摘 要： | 目的探讨高龄心房颤动患者应用调整剂量华法林抗凝治疗的疗效和安全性。方法选择2005年1月-2009年12月在阜阳市人民医院就诊的75例高龄（≥75岁）心房颤动患者，随机分为调整剂量华法林抗凝组（35例）和阿司匹林组（40例），分别给予华法林和阿司匹林治疗，华法林初始剂量2．5mg／d，依INR目标值（2．0—2．5）调整剂量，阿司匹林组给予阿司匹林100mg／d。随访1年，观察两组缺血性脑卒中及出血并发症的发生率。结果华法林组和阿司匹林组缺血性脑卒中发生率分别为5．7％和22．5％，差异有统计学意义（P〈0．05）。两组均无严重出血发生，轻微出血发生率分别为8．6％和7．5％，差异无统计学意义（P〉0．05）。结论严格控制INR（2．0～2．5）情况下，高龄心房颤动患者应用华法林抗凝治疗安全有效。
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| 关 键 词： | 心房颤动 华法林 缺血性脑卒中 出血 |
Antithrombotic Effect and Safety of Adjusted Dose Warfarin in Elderly Patients with Atrial Fibrillation |
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| SHAN Li-li. Antithrombotic Effect and Safety of Adjusted Dose Warfarin in Elderly Patients with Atrial Fibrillation[J]. Applied Journal Of General Practice, 2011, 0(8): 1205-1206 |
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| Authors: | SHAN Li-li |
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| Affiliation: | SHAN Li-li.Department of Gerontology,Fuyang People's Hospital,Fuyang 236004,Anhui,China |
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| Abstract: | Objective To investigate the antithrombotic effective and safe of adjusted dose warfarin senile patients with atrial fibrillation.Methods Seventy five patients older than 75 years with atrial fibrillation in our hospital from January 2005 to December 2009 were randomly divided into warfarin group(35 cases) and aspilin group(40 cases);the warfarin group was administrated with warfarin,while the aspilin group with aspilin.The original dose of warfarin was 2.5 mg/d,to adjusted dose according with the internati... |
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| Keywords: | Atrial fibrillation Warfarin Cerebral ischemic stroke Bleeding |
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