| fMRI观察情绪记忆编码中的持续效应和瞬时效应 |
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| 引用本文： | 吴津民,王海宝,余永强,潘志立,柏亚,胡孝朋,宋文.fMRI观察情绪记忆编码中的持续效应和瞬时效应[J].中国医学影像技术,2010,26(12):2243-2246. |
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| 作者姓名： | 吴津民 王海宝 余永强 潘志立 柏亚 胡孝朋 宋文 |
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| 作者单位： | 安徽医科大学第一附属医院放射科,安徽,合肥,230022 |
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| 基金项目： | 安徽省自然科学基金(50430601)、安徽省教育厅自然科学重点项目基金(KJ2010A186)。 |
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| 摘 要： | 目的 通过fMRI检测情绪记忆相关脑区激活情况,探讨情绪记忆编码中持续效应与瞬时效应脑机制,为进一步探讨情绪记忆障碍相关疾病的神经机制提供依据。方法 22名健康成人参加试验。试验材料为60幅负性情景(情绪记忆)和60幅中性情景图片。采用组块-事件相关混合设计模式。受试者在完成编码任务的同时接受fMRI扫描。利用SPM 2和SPSS 13.0分别对fMRI数据及行为学数据进行统计分析。结果 情绪记忆(3.15±0.14)和中性(2.25±0.08)图片记忆成绩(d')差异有统计学意义(t=2.79,P＝0.010)。fMRI结果显示,情绪记忆增强与内侧颞叶和前额叶不同亚区相关;右侧杏仁核(r=0.50,P=0.019)和眶额皮层(r=0.64,P=0.001)与持续效应显著相关,左侧杏仁核(r=0.65,P=0.001)和眶额皮层(r=0.65,P=0.001)与瞬时效应显著相关。结论 情绪记忆编码中持续效应和瞬时效应具有不同的神经机制,分别与右侧和左侧杏仁核及眶额皮层相关。
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| 关 键 词： | 情绪记忆 持续效应 瞬时效应 杏仁核 磁共振成像 |
| 收稿时间： | 2010/8/12 0:00:00 |
| 修稿时间： | 2010/8/29 0:00:00 |
Functional MRI in study of sustained and transient effects in encoding processes of emotional memory |
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| WU Jin-min,WANG Hai-bao,YU Yong-qiang,PAN Zhi-li,BAI Y,HU Xiao-peng and SONG Wen.Functional MRI in study of sustained and transient effects in encoding processes of emotional memory[J].Chinese Journal of Medical Imaging Technology,2010,26(12):2243-2246. |
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| Authors: | WU Jin-min WANG Hai-bao YU Yong-qiang PAN Zhi-li BAI Y HU Xiao-peng and SONG Wen |
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| Institution: | Department of Radiology, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, China;Department of Radiology, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, China;Department of Radiology, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, China;Department of Radiology, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, China;Department of Radiology, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, China;Department of Radiology, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, China;Department of Radiology, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, China |
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| Abstract: | |
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| Keywords: | Emotional memory Sustained effect Transient effect Amygdala Magnetic resonance imaging |
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