Ondansetron and droperidol in the prevention of postoperative nausea and vomiting |
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Authors: | Bugedo G Gonzalez J Asenjo C De la Cuadra J C Gajardo A Castillo L Muñoz H Dagnino J |
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Institution: | Departamento de Anestesiologia, Hospital Clinico Pontificia Universidad Catolica de Chile, PO Box 114-D, Santiago, Chile |
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Abstract: | We have performed a prospective, randomized, double-blind clinical study to
assess the efficacy of ondansetron, droperidol, or both, in preventing
postoperative emesis. We studied 242 patients undergoing biliary or
gynaecological surgery under general anaesthesia. Shortly before induction
of anaesthesia, patients received: saline i.v. (group I, n = 62);
droperidol 2.5 mg i.v. (group 2, n = 60); ondansetron 4 mg i.v. (group 3, n
= 57); or droperidol 2.5 mg with ondansetron 4 mg i.v. (group 4, n = 63).
Nausea occurred in 45%, 37%, 32% and 29% (P = 0.234) and vomiting in 23%,
17%, 9% and 5% (P = 0.016) of patients in groups 1, 2, 3 and 4,
respectively, during the first 24 h. Groups 2 and 4 had greater sedation
scores than group 1 during the first 3 h (P < 0.01). We conclude that
both droperidol and ondansetron showed a significant antiemetic effect,
ondansetron was not significantly better than droperidol, and the
combination of droperidol and ondansetron was better than droperidol but no
better than ondansetron alone.
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