肝病时5种急性时相反应蛋白测定的临床意义

各型肝炎和肝硬化病人PA明显降低,CRP显著升高,均以慢活肝、肝硬化、重肝为甚。急肝动态观察,上述指标两周开始恢复,康复出院时恢复正常,其变化与肝脏损伤程度相一致,因而可用于病情的判断及预后的估计。a_(1)—AT在急肝、慢活肝、肝硬化下降,重肝升高,a_1—AG多数肝病下降,急肝康复出院时两者虽有上升,但并未复常。合并检测这些指标可提高肝癌的阳性率,并可用于监护肝癌治疗的进展。CP在重肝、肝硬化、慢活肝显著降低,急肝各期变化不大,其临床意义有待探讨。

CLINICAL SIGNIFICANCE OF DETERMINATION OF FIVE ACUTE REACTIVE PROTEIN IN LIVER DISEASE

The level of prealbumin (PA) decreased markedly but the c response protein (CRP) rose notably in patients with various types of hepatitis and liver cirrhosis, especially in CAH liver cirrhosis and subacute hepatic-necrosis. Trie observation in acutehepalitis (AH)showed that the abnormal levels of PA and CRP persisted in 2 weeks and became normal when patients recovered. The variations of PA and CRP was consistency with the degree of injury in the liver. They were useful for the judgement of the disease condition and prognosis. The level of a1-AT decreased in patients with AH. CAH and cirrhosis and rose in subacute hepaticnecrosis. a1-AG declined in the majority of the patients with hepatitis, a1-AT and a1-AG rose either when patients recovered from AH, but was not normal either. The combined determination of a1-AT and a1-AG may not only increase the positive rate of liver cancer, but also can monitor the progress of the tumor dasing treatment. The level of CP fell notably in subacute hepaticnecrosis, cirrhosis and CAH and did not change in AH. The clinical significence of the determination on CP still waits to be investigated.