| 胃上皮细胞凋亡与消化性溃疡愈合的关系 |
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| 引用本文： | 关景明,程艳秋,赵瑞波. 胃上皮细胞凋亡与消化性溃疡愈合的关系[J]. 哈尔滨医科大学学报, 2000, 34(2): 109-110,F003 |
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| 作者姓名： | 关景明 程艳秋 赵瑞波 |
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| 作者单位： | 哈尔滨医科大学附属第二医院消化内科(关景明，程艳秋，许军)，哈尔滨医科大学病理学教研室!黑龙江哈尔滨150086(赵瑞波，毕彦忠，黄淇) |
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| 摘 要： | 目的 观察幽门螺杆菌（ＨＰ）阳笥的胃溃疡病人有在溃疡愈合前后胃上皮细胞凋亡及ＨＰ检测的情况。方法 采用检测ＤＮＡ裂解的末端脱氧核苷酸转移（ＴｄＴ）介导的ｄＵＴＰ缺口号档端标记法（ＴＵＮＥＬ），在原位标记凋亡的胃上皮细胞。结果 溃疡愈合胃上皮细胞凋亡指数下降，与愈合前相比两者间有显著性差异（Ｐ，０．０５）。溃疡愈合ＨＰ全部阴转，ＨＰ的检出密度与胃上皮细胞凋亡指数之间呈正相关性（ｒ＝０．８０，Ｐ〈０．
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| 关 键 词： | 细胞凋亡 幽门螺杆菌 消化性溃疡 胃上皮细胞 |
Relationship of gastric epithelial cell apoptosis and peptic ulcer healing |
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| GUAN Jing-ming,CHENGYan-qiu,ZHAO Rui-bo,et al. Relationship of gastric epithelial cell apoptosis and peptic ulcer healing[J]. Journal of Harbin Medical University, 2000, 34(2): 109-110,F003 |
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| Authors: | GUAN Jing-ming CHENGYan-qiu ZHAO Rui-bo et al |
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| Affiliation: | GUAN Jing-ming,CHENGYan-qiu,ZHAO Rui-bo,et al;(Department of Gastroenterology,The Second Affiliated Hospital,Harbin Medical;University,Harbin 150086,China) |
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| Abstract: | Objective To investigate the gastric epithelial cell apoptosis and Helicobacter pylori (HP) detection in the patient showing the positive HP with peptic ulcer before and after ulcer healing.Methods By use of the method of terminal deoxynucleotidyl (TdT) mediated dUTP nick ending labelling (TdT mediated dUTP nick ending labelling)which is adopted to detect DNA splitting,we labelled apoptosis gastric epithelial cell.Results The gastric epithelial cell apoptosis index decreased after the ulcer healing.There was significant difference between before and after the ulcer healing( P <0.05).The HP detection all turned negative after the ulcer healing.There was positive correlation between the density of HP and the gastric epithelial cell apoptosis index(r=0.80, P <0.05).Conclusion HP can induce gastric epithelial cell apoptosis and result in formation and recurrence of ulcer. |
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| Keywords: | apoptosis Helicobacter pylori peptic ulcer |
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