高血压与冠心病患者血浆氨基脲敏感性胺氧化酶活性和甲醛浓度改变的研究

目的 研究原发性高血压（高血压）、冠状动脉粥样硬化性心脏病（冠心病）患者血浆中内源性甲胺浓度、氨基脲敏感性胺氧化酶活性以及内源性甲醛浓度的变化,以及3者之间的相关性,进一步探讨其临床意义.方法 入选健康人42名、高血压34例、冠心病37例、冠心病合并高血压25例,应用高效液相色谱仪检测血浆甲胺浓度、氨基脲敏感性胺氧化酶活性以及甲醛浓度.结果 4组甲胺浓度比较,差异无统计学意义（P＞0.05）.高血压组、冠心病组、冠心病合并高血压组氨基脲敏感性胺氧化酶活性均较对照组显著升高,差异有统计学意义（P＜0.01）.冠心病并高血压组的氨基脲敏感性胺氧化酶活性高于单纯高血压组,差异有统计学意义（P＜0.05）；也高于单纯冠心病组,差异有统计学意义（P＜0.05）.高血压组、冠心病组、冠心病合并高血压组甲醛浓度与对照组比较,均显著升高,差异有统计学意义（P＜0.01和P＜0.05）；高血压组、冠心病组、冠心病合并高血压组间甲醛浓度比较,差异无统计学意义（P＞0.05）.氨基脲敏感性胺氧化酶活性与甲醛浓度存在直线相关性（r=0.4463,P＜0.01）.结论 血浆的氨基脲敏感性胺氧化酶活性和甲醛浓度在高血压、冠心病患者明显升高,提示氨基脲敏感性胺氧化酶活性和甲醛浓度异常升高可能是动脉粥样硬化发生的始动因素之一.

Changes of plasma semicarbazide-sensitive amine oxidase activity and formaldehyde concentration in patients with hypertension or coronary heart disease

Objectives To determine plasma with methylamine,formaldehyde and semicarbazide-sensitive amine oxidase （SSAO） activity in patients with hypertension or coronary heart disease （CHD）, to analyze the relationship among methylamine, formaldehyde and SSAO, and to discuss the clinical significance among them. Methods Totally 42 healthy controls,34 patients with hypertension,37 patients with CHD and 25 patients with CHD combined hypertension were enrolled in this study. The plasma with methylamine, SSAO activity and formaldehyde were analyzed by high-performance liquid chromatography （HPLC）. Results Methylamine concentration had no significant difference among the 4 groups（P〉0.05）. SSAO activities in hypertension group, CHD group and CHD combined hypertension group were significantly higher than that in control group（P〈0.01 ）. SSAO activity in CHD combined hypertension group was significantly higher than those in hypertension group and CHD group（P〈0.05）. Formaldehyde concentrations in hypertension group, CHD group and CHD combined hypertension group were significantly higher than that in control group（P〈0.01 or P〈0.05）, but there was no significant difference among patient groups （P〉0.05）. There were significant correlations of SSAO with formaldehyde （r=0.4463, P〈0.01 ）. Conclusions Plasma semicarbazide-sensitive amine oxidase activity and formaldehyde concentration in patients with hypertension or CHD increase significantly, indicating that the abnormal increase of semicarbazide-sensitive amine oxidase activity can be an important factor of the initiation and progression of coronary atherosclerotic diseases.