冠心病患者血浆CXCL16与斑块稳定性的相关性分析

目的 探讨血浆CXCL16与冠心病及粥样斑块稳定性的关系.方法 检测正常对照组16例、急性冠状动脉（冠脉）综合征组58例、稳定型心绞痛组22例的血浆CXCL16、基质金属蛋白酶（matrix metalloproteinases,MMP）-1、MMP-2、MMP-9及细胞核因子-κB （nuclear factor-κB,NF-κB）浓度,并进行相关性分析.结果 与对照组比较,稳定型心绞痛组和急性冠脉综合征组血浆CXCL-16、MMP-2、MMP-9及NF-κB浓度均显著升高,差异有统计学意义（P＜0.05）；与稳定型心绞痛组比较,急性冠脉综合征组血浆CXCH6、MMP-2及MMP-9浓度显著升高,差异有统计学意义（P＜0.05）.相关性分析提示CXCL16与高密度脂蛋白呈负相关（r=-0.368,P＜0.05）,与C反应蛋白（r=0.392,P＜0.05）、MMP-2 （r=0.416,P＜0.05）、MMP-9 （r=0.343,P＜0.05）及NF-κB （r=0.447,P＜0.05）呈显著正相关.结论 CXCH6可能通过NF-κB调节MMPs的水平进而影响粥样硬化斑块稳定性,介导冠状动脉粥样硬化性心脏病（冠心病）的发生及发展.

Correlation between plasma CXCL16 and plaque stability in patients with coronary heart disease

Objectives To explore the correlation of plasma CXCL16 with plaque stability in patients with coronary heart disease.Methods Plasma concentrations of CXCL16,matrix metalloproteinases （MMP）-1,MMP-2,MMP-9 and nuclear factor-κB （NF-κB） in control group （n=16）,acute coronary syndromes （ACS） group （n=58） and stable angina pectoris （SAP） group （n=22） were measured and analyzed.Results Plasma concentrations of CXCL16,MMP-2,MMP-9 and NF-κB were significantly increased in both ACS and SAP groups than those in control group （P〈0.05）.As compared to those in SAP group,plasma concentrations of CXCL16,MMP-2 and MMP-9 were significantly elevated in ACS group （P〈0.05）.Correlation analysis showed that CXCL16 was negatively correlated with high-density lipoprotein （r=-0.368,P〈0.05）,but was positively correlated with C-reactive protein （r=0.392,P〈0.05）,MMP-2 （r=0.416,P〈0.05）,MMP-9 （r=0.343,P〈0.05） and NF-κB （r=0.447,P〈0.05）.Conclusions CXCL16 may regulate the MMPs levels through affecting NF-κB,thereby affecting atherosclerotic plaque stability and mediating the progress of coronary heart disease.