|
|||||
|
|
SNCA multiplication is not a common cause of Parkinson disease or dementia with Lewy bodies |
|
| Authors: | Johnson J Hague S M Hanson M Gibson A Wilson K E Evans E W Singleton A A McInerney-Leo A Nussbaum R L Hernandez D G Gallardo M McKeith I G Burn D J Ryu M Hellstrom O Ravina B Eerola J Perry R H Jaros E Tienari P Weiser R Gwinn-Hardy K Morris C M Hardy J Singleton A B |
| Affiliation: | Laboratory of Neurogenetics, National Institute on Aging, NIH, Bethesda, MD 20892, USA. |
| Abstract: | The authors recently have shown that triplication of the alpha-synuclein gene (SNCA) can cause Parkinson disease (PD) and diffuse Lewy body disease within the same kindred. The authors assessed 101 familial PD probands, 325 sporadic PD cases, 65 patients with dementia with Lewy bodies, and 366 neurologically normal control subjects for SNCA multiplication. The authors did not identify any subjects with multiplication of SNCA and conclude this mutation is a rare cause of disease. |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ | |